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Correcting a pathogenic mitochondrial DNA mutation by base editing in mice.
Sci Transl Med
January 2025
Graduate Program in Human Genetics, University of Miami Miller School of Medicine, 1501 NW 10th Avenue (M-860), Miami, FL 33136, USA.
Primary mitochondrial disorders are most often caused by deleterious mutations in the mitochondrial DNA (mtDNA). Here, we used a mitochondrial DddA-derived cytosine base editor (DdCBE) to introduce a compensatory edit in a mouse model that carries the pathological mutation in the mitochondrial transfer RNA (tRNA) alanine (mt-tRNA) gene. Because the original m.
View Article and Find Full Text PDFTranexamic dosing for major joint arthroplasty in adult patients with chronic kidney disease: A pharmacokinetic study and new dosing regimen.
Anesthesiology
January 2025
Department of Anesthesiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Background: Tranexamic acid is an anti-fibrinolytic agent routinely used during hip and knee joint replacement surgery to minimize bleeding. Chronic kidney disease is a common chronic health problem seen among adults requiring major arthroplasty surgery. Tranexamic acid is renally cleared and may accumulate in chronic kidney disease.
View Article and Find Full Text PDFPerceived Preparedness for the Clinical Practice Among Medical Interns: A Cross-Sectional Study.
Adv Med Educ Pract
January 2025
Health Professions Education Department, Gulf Medical University (GMU), Ajman, United Arab Emirates.
Background: Measurement of medical graduates' perception of their internship program can help to improve the program to guarantee the general satisfaction of medical interns and enhance their clinical training.
Objective: To evaluate the medical interns' perceived preparedness for clinical practice and investigate the contributing elements.
Method: The study was carried out to include 109 medical interns.
Mothers' experiences as legal guardian of children's phlebitis during hospitalization in Indonesia: A phenomenological study.
Belitung Nurs J
January 2025
STIKes Mitra Keluarga, West Java, Indonesia.
Background: Peripheral intravenous catheter (PIVC) insertion is a common procedure performed by nurses for hospitalized children, but phlebitis-an inflammation of the vein-is a frequent complication. The response of the mother, as the child's primary caregiver, plays a key role in the healing process when phlebitis occurs.
Objective: This study aimed to explore mothers' experiences and perceptions regarding the occurrence and management of phlebitis in their children during hospitalization.
Eosinophilic granulomatosis with polyangiitis; a distinctive presentation with myocarditis and autoimmune haemolytic anaemia: case report.
Front Cardiovasc Med
January 2025
Family and Community Medicine Department, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia.
Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is an extremely rare type of vasculitis characterized by inflammation within small blood vessels or tissues that may cause damage to the lungs, heart, kidneys, and other organs. Here, we present a rare case of EGPA with cardiac involvement that presented with acute heart failure.
Clinical Findings: A 44-year-old woman with a history of bronchial asthma and sinusitis presented with fever, shortness of breath, fatigue, unintentional weight loss, and polyarthritis.
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