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Intravenous branched-chain amino acid administration for the acute treatment of hepatic encephalopathy: a systematic review and meta-analysis.
J Intensive Care
January 2025
Showa General Hospital, Kodaira-Shi, Tokyo, 187-8510, Japan.
Background: Hepatic encephalopathy (HE) is a severe complication of acute hepatic failure requiring urgent critical care management. Branched-chain amino acids (BCAAs) such as leucine, isoleucine, and valine have been investigated as potential treatments to improve outcomes in patients with acute HE. However, the effectiveness of BCAA administration during the acute phase remains unclear.
View Article and Find Full Text PDFThe Esophageal Response to Distension on Functional Lumen Imaging Probe Panometry Is Minimally Changed by Conscious Sedation in Healthy Asymptomatic Subjects.
J Neurogastroenterol Motil
January 2025
Kenneth C. Griffin Esophageal Center of Northwestern Medicine, Rockford, IL, USA.
Background/aims: Functional lumen imaging probe (FLIP) Panometry has demonstrated utility in the assessment of esophageal motility as a complement to existing methodologies like high-resolution manometry. However, as FLIP is typically performed with sedation during routine endoscopy, there is potential for impact of sedation agents on esophageal motility. We aim to examine the effects of conscious sedation with midazolam and fentanyl on FLIP Panometry metrics and classification.
View Article and Find Full Text PDFBreaking Down Complications With Locoregional Anesthesia: A Game-Changer for Pain Management in Pediatric Emergencies.
Cureus
December 2024
Anesthesia and Intensive Care Unit, Giuseppe Mazzini Hospital, Teramo, ITA.
The management of postoperative pain in pediatric patients undergoing emergency surgical procedures, particularly in non-pediatric hospitals, presents significant challenges due to the unique physiological requirements of children. The utilization of opioid analgesia may result in severe complications, necessitating a transition toward multimodal analgesia, which integrates various pain management strategies to enhance effectiveness while mitigating adverse effects. Locoregional anesthesia techniques, such as fascial plane blocks, provide targeted pain alleviation, reducing dependence on opioids.
View Article and Find Full Text PDFCapillary Filtration of Plasma is Accelerated During General Anesthesia: A Secondary Population Volume Kinetic Analysis.
J Clin Pharmacol
January 2025
Research and Development, Karolinska Institutet at Danderyds Hospital, (KIDS), Stockholm, Sweden.
How infusion fluids are distributed and eliminated is of importance to how much and how fast they should be administered. This manuscript applies population pharmacokinetic modeling to intravenous infusions of crystalloid fluid, which is a common therapy in hospital care and mandatory during surgery. The analysis was based on the hemodilution and urine output measured during and after 262 infusions of 1647 ± 461 mL (mean ± SD) of fluid over 30 min in adults.
View Article and Find Full Text PDFDrug Extravasation in a Tertiary Referral Children Hospital: A Prospective Cohort Study.
Clin Pediatr (Phila)
January 2025
Pediatric Dermatology Division, Department of Pediatrics, Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Extravasation injuries are prevalent in pediatric hospitals and often result in tissue damage and extended hospital stays. However, limited data exist regarding risk factors for extravasation in children. This study aimed to identify these risk factors in pediatric patients receiving intravenous (IV) therapy.
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