A one-step synthesis of a deuterated paclitaxel analogue: 10-deacetoxy-(10alpha-2H)paclitaxel.

Bioorg Med Chem Lett

Department of Medicinal Chemistry, University of Kansas, Lawrence 66045, USA.

Published: December 1999

10-Deacetoxy-(10alpha-2H)paclitaxel was prepared in one step via the samarium diiodide mediated deoxygenation of paclitaxel in the presence of D2O.

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http://dx.doi.org/10.1016/s0960-894x(99)00609-5DOI Listing

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