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Positive surgical margins after breast-conserving surgery for ductal carcinoma in-situ: does histologic grade or estrogen receptor status matter?
Breast Cancer Res Treat
June 2023
Division of Surgical Oncology, Department of Surgery, Baylor University Medical Center, 3410 Worth Street, Suite 235, Dallas, TX, 75246, USA.
Article Synopsis
- The study investigates the relationship between histologic grade and estrogen receptor (ER) status in ductal carcinoma in situ (DCIS) patients who have positive surgical margins after breast-conserving surgery (BCS).
- A total of 615 female patients were reviewed, with findings showing that larger tumor size is a key risk factor for positive margins, while negative ER status also significantly correlates with this outcome.
- The results suggest that understanding these factors can guide changes in surgical practices to lower the risk of positive margins, especially in patients with large, ER-negative DCIS.
Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye.
JAMA
February 2021
Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.
Article Synopsis
- Exfoliation syndrome is a systemic disorder characterized by the buildup of abnormal protein aggregates in the eye, leading to increased risk of glaucoma and potential blindness.
- The study aimed to explore the association between exfoliation syndrome and rare genetic variants that could affect protein function, using whole-exome sequencing on participants from 14 countries over 20 years.
- Results showed that individuals with exfoliation syndrome were more likely to have harmful genetic variants in the CYP39A1 gene compared to those without the condition, indicating a potential genetic factor in the disorder.
Validation of diagnostic codes and epidemiologic trends of Huntington disease: a population-based study in Navarre, Spain.
Orphanet J Rare Dis
February 2021
Department of Health Sciences, Universidad Pública de Navarra, IdiSNA, Pamplona, Spain.
Background: There is great heterogeneity on geographic and temporary Huntington disease (HD) epidemiological estimates. Most research studies of rare diseases, including HD, use health information systems (HIS) as data sources. This study investigates the validity and accuracy of national and international diagnostic codes for HD in multiple HIS and analyses the epidemiologic trends of HD in the Autonomous Community of Navarre (Spain).
View Article and Find Full Text PDF[Lyme nephritis in humans: Physio-pathological bases and spectrum of kidney lesions].
Nephrol Ther
June 2019
Service de néphrologie-dialyse, centre hospitalier de Cahors, 335, rue du président-Wilson, 46000 Cahors, France; Département de néphrologie et transplantation d'organes, CHU Rangueil, 1, avenue du Professeur-Jean-Poulhès, 31400 Toulouse, France; Inserm U563, IFR-BMT, CHU Purpan, 105, avenue de Cassalardit, 31300 Toulouse, France; Université Paul Sabatier, route de Narbonne, 31330 Toulouse, France.
Known in less than half a century, borreliosis, or Lyme disease, is a zoonosis caused by the tick bite. It is the most common vector disease in Europe and the United States. Borrelia burgdorferi sensu lato, the bacterium in question, is fitted with a "cunning device" that allows it to trick the immune system and implant the infection chronically.
View Article and Find Full Text PDFRedefining the Influence of Ethnicity on Simultaneous Kidney and Pancreas Transplantation Outcomes: A 15-year Single-center Experience.
Ann Surg
January 2020
Comprehensive Transplant Institute, Departments of Medicine and Surgery, University of Alabama at Birmingham, Birmingham, AL.
Objective: To examine the largest single-center experience of simultaneous kidney/pancreas transplantation (SPK) transplantation among African-Americans (AAs).
Background: Current dogma suggests that AAs have worse survival following SPK than white recipients. We hypothesize that this national trend may not be ubiquitous.
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