Background: Little is known about the mechanisms underlying recovery from hydronephrosis. Using a rat kidney model, we investigated the possible contribution of growth factors during regeneration after hydronephrosis.
Methods: After the unilateral ureteral obstruction for 7 days, the obstruction was released by ureterocystostomy. Epidermal growth factor (EGF), hepatocyte growth factor (HGF) and transforming growth factor-beta1 (TGF-beta1) were studied using immunohistochemistry and semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR).
Results: The immunoreaction of EGF in the medulla of both obstructed and contralateral kidneys increased after releasing the obstruction. The release of ureteral obstruction brought further increased immunoreaction of HGF to both the cortex and the medulla of the contralateral kidney. The immunoreaction of TGF-beta1 also increased in the interstitium especially around the blood vessels in the post-obstructed kidney. The expression of HGF and EGF mRNA in both kidneys and TGF-beta1 mRNA in the obstructed kidney were increased after releasing the obstruction.
Conclusions: These results suggest that various growth factors may be involved in the post-obstructive tubular recovery and interstitial damage in the rat kidney.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1046/j.1442-2042.1999.00121.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recent Prospectives of Cellular Signaling Role for Mammary Gland Carcinogenesis.
Anticancer Agents Med Chem
January 2025
Department of Pharmaceutical Sciences, Lucknow University, Lucknow, UP, India.
In women globally, breast cancer ranks as the second most frequent cause of cancer-related deaths, making up about 25% of female cancer cases, which is pretty standard in affluent countries. Breast cancer is divided into subtypes based on aggressive, genetic and stage. The precise cause of the problem is still unknown.
View Article and Find Full Text PDFImpact of increasingly complex cell culture conditions on the proteome of human periodontal ligament stem cells.
Regen Med
January 2025
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Aims: Human periodontal ligament stem cells (hPDLSCs) exhibit an enormous potential to regenerate periodontal tissue. However, their translatability to the clinical setting is constrained by technical difficulties in standardizing culture conditions. The aim was to assess complex culture conditions using a proteomic-based protocol to standardize multi-layer hPDLSC cultivation methodology.
View Article and Find Full Text PDFProfessional judgement: a social practice perspective on a multiple mini-interview for specialty training selection.
BMC Med Educ
January 2025
Division of Learning and Teaching, Charles Sturt University, Bathurst, NSW, Australia.
Background: Interviewers' judgements play a critical role in competency-based assessments for selection such as the multiple-mini-interview (MMI). Much of the published research focuses on the psychometrics of selection and the impact of rater subjectivity. Within the context of selecting for entry into specialty postgraduate training, we used an interpretivist and socio-constructivist approach to explore how and why interviewers make judgments in high stakes selection settings whilst taking part in an MMI.
View Article and Find Full Text PDFContext: Anemia is a medical condition resulting from a reduction in the number of red blood cells below the reference range. It is a major public health problem, particularly among adolescents, as it can have negative effects on cognitive performance, growth and reproduction. This study aims to assess the determinants of anemia among adolescents in schools in the city of Douala.
View Article and Find Full Text PDFResponse of Kapok seedlings were irrigated with water of different qualities and heavy metal contents for foliar application of antioxidants.
BMC Plant Biol
January 2025
Horticulture Department, Faculty of Agriculture, Fayoum University, Fayoum, 63514, Egypt.
Background: The imbalance between Egypt's water requirements and supply necessitates the use of unconventional water sources, such as treated sewage water (TSW) and agricultural drainage water (ADW), to combat water scarcity. This study investigated the effects of foliar glycine betaine (GB) on vegetative growth parameters, physiological characteristics, photosynthetic pigments, leaf element contents, anatomical leaf structures, and antioxidant activity. The experiment was conducted in two successive seasons (2021/2022 and 2022/2023) using Kapok seedlings irrigated with ADW and TSW at different mixing ratios with normal irrigation water (NIW) (25%, 50%, 75%, and 100%), combined with foliar spraying of GB at concentrations of 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!