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Childhood Blindness: A Rare Case of Leber Hereditary Optic Neuropathy in a 16-Year-Old Egyptian Patient.
Cureus
October 2024
Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, EGY.
Leber hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial genetic disorder that is rarely encountered in daily clinical practice. It presents by an acute or subacute onset and a progressive course of painless, bilateral, sequential severe loss of vision, mostly seen in young males. Mutations in the mitochondrial DNA in these patients lead to dysfunction at complex I of the respiratory chain, causing a selective degeneration of the retinal ganglion cells and predisposition toward the development of the clinical symptoms.
View Article and Find Full Text PDFPost-radiation optic neuropathy.
Pract Neurol
September 2024
University of Toronto, Faculty of Medicine, Department of Ophthalmology and Vision Sciences, Toronto, Ontario, Canada.
Article Synopsis
- A middle-aged man experienced gradual vision loss in both eyes, eventually leading to no light perception, with a history of having a pituitary tumor surgically removed.
- MRI scans showed enhancement in the optic nerves, but cerebrospinal fluid tests were normal.
- The diagnosis was post-radiation optic neuropathy, a condition that can occur 1-1.5 years after radiotherapy targeting the visual areas, with no definitive treatment, although hyperbaric oxygen therapy shows potential benefits.
New-Onset Paroxysmal Atrial Fibrillation in a Healthy Male With Post-COVID-19 Painless Thyroiditis: A Case Report.
Cureus
August 2024
Emergency Medicine, HCA Healthcare, Riverside Community Hospital, Riverside, USA.
Painless thyroiditis is a variant of thyroiditis without the typical neck pain and is otherwise similar to subacute thyroiditis, which is a known post-viral condition and has been associated with coronavirus disease 2019 (COVID-19) infections. While it is usually self-limiting, it can lead to thyrotoxicosis that can predispose individuals to cardiac dysrhythmias, including atrial fibrillation. There has been a clear association between COVID-19 and subacute thyroiditis with a few case reports describing atrial fibrillation.
View Article and Find Full Text PDFArticle Synopsis
- Wernicke encephalopathy (WE) can lead to various neuro-ophthalmic symptoms like vision loss, and this case highlights a 53-year-old woman who experienced bilateral painless vision decline alongside other neurological issues.* -
- Despite elevated inflammatory markers and a thorough work-up revealing no clear cause, brain MRI indicated possible WE, prompting immediate high-dose thiamine treatment, which led to significant improvement.* -
- The case stresses the importance of considering vision loss in Wernicke-Korsakoff syndrome (WKS) patients and suggests that while checking thiamine levels is important, starting treatment based on clinical suspicion is often necessary and safe.*
A Comprehensive Review of Leber Hereditary Optic Neuropathy and Its Association with Multiple Sclerosis-Like Phenotypes Known as Harding's Disease.
Eye Brain
July 2024
Department of Ophthalmology, University of Jeddah, Jeddah, Saudi Arabia.
Leber Hereditary Optic Neuropathy (LHON) stands as a distinctive maternally inherited mitochondrial disorder marked by painless, subacute central vision loss, primarily affecting young males. This review covers the possible relationship between LHON and multiple sclerosis (MS), covering genetic mutations, clinical presentations, imaging findings, and treatment options. LHON is associated with mutations in mitochondrial DNA (mtDNA), notably m.
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