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Poincaré plot analysis of electrocardiogram uncovers beneficial effects of omaveloxolone in a mouse model of Friedreich ataxia.
Heart Rhythm
January 2025
Department of Molecular Biosciences, University of California, Davis, California; Department of Basic Sciences, California Northstate University, Elk Grove, California. Electronic address:
Background: Friedreich ataxia (FA) is a rare inherited neuromuscular disorder whereby most patients die of lethal cardiomyopathy and arrhythmias. Mechanisms leading to arrhythmic events in patients with FA are poorly understood.
Objective: This study aimed to examine cardiac electrical signal propagation in a mouse model of FA with severe cardiomyopathy and to evaluate effects of omaveloxolone (OMAV), the first Food and Drug Administration-approved therapy.
Relationship between erectile dysfunction and alexithymia in male patients with implantable cardioverter defibrillators: a cross-sectional study.
Front Psychiatry
October 2024
Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Background: Implantable Cardioverter-Defibrillator (ICD) implantation is a life-saving intervention for individuals at risk of life-threatening arrhythmias. However, the psychosocial impact of ICD implantation extends beyond its cardiovascular benefits, potentially influencing emotional well-being and sexual health. This can lead to erectile dysfunction, which, is often associated with alexithymia.
View Article and Find Full Text PDFPrevalence of Cardiac Arrhythmias in Transgender and Nonbinary Adult Community Health Center Patients.
LGBT Health
November 2024
Section of General Internal Medicine, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
Article Synopsis
- The study investigated the prevalence of cardiac arrhythmias among transgender and nonbinary (TGNB) adults using medical records from a specialized care center over a period from 2010 to 2021.
- Out of 49,862 adults, 7121 identified as TGNB, showing a low prevalence of arrhythmias (ranging from 0.7% to 1.5%), with transgender individuals having similar odds of arrhythmias compared to cisgender men but higher odds compared to cisgender women.
- The findings suggest that the prevalence of arrhythmias is similar among TGNB adults regardless of whether they were undergoing gender-affirming hormone therapy (GAHT), highlighting the need for further research on this topic
The dyadic effects of posttraumatic stress symptoms on the regulation of respiratory sinus arrhythmia following an acute stress induction among couples.
Psychol Trauma
August 2024
Department of Psychology, Binghamton University (State University of New York).
Objective: Posttraumatic stress symptoms (PTSS) can have detrimental influences on both individual and couple functioning, including how individuals respond to stressors and regulate emotions. Respiratory sinus arrhythmia (RSA) can serve as a key indicator of emotion regulation; however, few studies have examined psychophysiological stress reactions within a couple's context.
Method: Forty-three couples ( = 86 individuals) with a trauma history were assessed for PTSS and RSA at baseline.
Atopic dermatitis is associated with an increased risk of cardiovascular diseases: a large-scale, propensity-score matched US-based retrospective study.
Clin Exp Dermatol
October 2024
Institute and Comprehensive Centre for Inflammation Medicine, University Hospital Schleswig Holstein (UKSH), Campus Lübeck, Lübeck, Germany.
Background: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease characterized by intense itch, and impacting heavily on patients' and caregivers' quality of life. Its clinical presentation is accompanied by a variety of comorbidities associated with type 2 inflammation, such as asthma, hay fever and food allergies. However, current data on cardiovascular comorbidities are inconsistent.
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