The Mitsuda test, which measures the specific immune response against intradermally injected lepromin, has a high prognostic value for susceptibility or resistance to the lepromatous form of leprosy. A sib-pair linkage analysis between the Mitsuda response and the NRAMP1 gene was done among 20 nuclear families with leprosy (totaling 118 sibs) from Ho Chi Minh City, Vietnam. All family subjects were genotyped for several intragenic and flanking NRAMP1 markers, leading to the definition of a fully informative NRAMP1 haplotype. Significant linkage was observed between NRAMP1 and Mitsuda reaction when considered either as a quantitative (P<.002) or as a categorical (P=.001) trait. Separate analyses among healthy and affected sibs showed evidence for linkage in both subsamples, indicating that linkage between the Mitsuda reaction and NRAMP1 is independent of leprosy status. These results support the view that NRAMP1 plays a regulatory role for the development of acquired antimycobacterial immune responses as determined by in vivo Mitsuda test reaction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1086/315174 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Catalytic Mechanism of a Highly Active Cobalt Chlorin Complex for Photocatalytic Water Oxidation.
Inorg Chem
December 2024
Research Center for Artificial Photosynthesis (ReCAP), Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi, Osaka 558-8585, Japan.
Highly active catalysts for electrocatalytic and photocatalytic water oxidation are strongly demanded to realize artificial photosynthesis. A cobalt complex with a chlorin derivative ligand (Co(Ch)) exhibited high activity for electrocatalytic water oxidation with an overpotential of 0.45 V at pH 9.
View Article and Find Full Text PDFRapid multiplex immunohistochemistry for characterizing tumor-immune microenvironment.
Heliyon
July 2024
Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Article Synopsis
- Intratumoral immune profiles play a crucial role in determining prognosis and treatment effectiveness, potentially leading to personalized treatments using specific biomarkers.
- A new 6-marker rapid multiplex immunohistochemistry (IHC) method was created, streamlining the process originally based on a 14-marker system, making it faster and less complex.
- Validation studies demonstrated that this new method reliably assessed immune features and densities in cancer tissues, which could improve the way we understand and treat tumors clinically.
Multiplex Real-Time PCR-Based Newborn Screening for Severe Primary Immunodeficiency and Spinal Muscular Atrophy in Osaka, Japan: Our Results after 3 Years.
Genes (Basel)
February 2024
Department of Laboratory Medicine, Osaka Women's and Children's Hospital, Izumi 594-1101, Japan.
Article Synopsis
- In newborn screening (NBS), integrating multiplex assays can enhance the detection of new target diseases, such as severe primary immunodeficiency (PID) and spinal muscular atrophy (SMA).
- Recent advancements in testing technology, like the use of quantitative real-time polymerase chain reaction (qPCR), allow simultaneous screening for these conditions, improving early diagnosis and treatment.
- In Osaka, Japan, a multiplex TaqMan qPCR assay was successfully implemented, identifying cases of PID and SMA among over 105,000 newborns, showcasing its effectiveness in large-scale NBS programs.
Biosimilar(BS)drugs have recently been introduced owing to concerns with healthcare economics. In this report, we present a case in which a patient discontinued bevacizumab treatment following an allergic reaction to a BS formulation of bevacizumab but was able to safely continue treatment by switching to an original bevacizumab formulation in the late-line setting. The patient was a 66-year-old man diagnosed with unresectable colorectal cancer with synchronous multiple liver metastases.
View Article and Find Full Text PDFThe AT-hook protein AHL29 promotes Bacillus subtilis colonization by suppressing SWEET2-mediated sugar retrieval in Arabidopsis roots.
Plant Cell Environ
April 2024
Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan ROC.
Beneficial Bacillus subtilis (BS) symbiosis could combat root pathogenesis, but it relies on root-secreted sugars. Understanding the molecular control of sugar flux during colonization would benefit biocontrol applications. The SWEET (Sugar Will Eventually Be Exported Transporter) uniporter regulates microbe-induced sugar secretion from roots; thus, its homologs may modulate sugar distribution upon BS colonization.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!