This study investigates the anti-inflammatory effects of 1-(2-chlorophenyl)-N-methyl-N(1-methylpropyl)-3-isoquinoline carboxamide and 7-chloro-5-(4-chlorophenyl)-1, 3-dihydro-1-methyl-2-H-1,4-benzodiazepin-2-one in paw oedema induced by carrageenan in mice. Pretreatment (24 h) with both ligands inhibited oedema formation in at different doses (0.00001-10 mg/kg, i.p.) with range of inhibition of 25% to 70%, in animals with or without adrenal glands. These results demonstrate, for the first time, an in vivo anti-inflammatory property of peripheral benzodiazepine receptor ligands.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0014-2999(99)00745-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Loncastuximab tesirine with rituximab in patients with relapsed or refractory follicular lymphoma: a single-centre, single-arm, phase 2 trial.
Lancet Haematol
January 2025
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: Preliminary data suggest promising activity of loncastuximab tesirine in follicular lymphoma, and synergistic activity between rituximab-induced cytotoxicity and loncastuximab tesirine. In this study, we evaluated loncastuximab tesirine combined with rituximab for second-line and later treatment of follicular lymphoma.
Methods: We did a single-arm, investigator-initiated, phase 2 trial at Sylvester Comprehensive Cancer Center in Miami, FL, USA.
Peripheral GABA receptors - Physiological relevance and therapeutic implications.
Pharmacol Ther
November 2024
Department of Pharmacology, University of Belgrade - Faculty of Pharmacy, Belgrade 11000, Serbia. Electronic address:
The role of γ- aminobutyric acid (GABA) and GABA receptors is not only essential for neurotransmission in the central nervous system (CNS), but they are also involved in communication in various peripheral tissues such as the pancreas, liver, kidney, gastrointestinal tract, trachea, immune cells and blood vessels. GABA receptors located outside the CNS ("peripheral GABA receptors") enable both neuronal and non-neuronal GABA-ergic signaling in various physiological processes and are generally thought to have similar properties to the extrasynaptic receptors in the CNS. By activating these peripheral receptors, GABA and various GABA receptor modulators, including drugs such as benzodiazepines and general anesthetics, may contribute to or otherwise affect the maintenance of general body homeostasis.
View Article and Find Full Text PDFPost-mortem distribution of MDPHP in a fatal intoxication case.
J Anal Toxicol
November 2024
FT-LAB, Department of Health Science, University of Florence.
Article Synopsis
- - The study investigates the distribution of the synthetic cathinone MDPHP in post-mortem specimens of a 30-year-old man, highlighting high concentrations in urine and gastric content, suggesting potentially lethal levels.
- - Various toxicological analyses, including gas chromatography and liquid chromatography, were used to measure MDPHP and other substances, with no evidence of recent cocaine injection found.
- - Findings indicated that MDPHP levels were significantly higher compared to previously reported fatal cases, leading the researchers to conclude that the individual's death was likely due to MDPHP overdose.
Clinical phenotype and management of sound-induced pain: Insights from adults with pain hyperacusis.
J Pain
November 2024
Department of Neuroscience and Center for Advanced Pain Studies, The University of Texas at Dallas, 860 N. Loop Rd., Richardson, TX 75080, USA. Electronic address:
Pain hyperacusis, also known as noxacusis, causes physical pain in response to sounds that do not bother most people. How sound causes excruciating pain that can last for weeks or months is not well understood, resulting in a lack of effective treatments. To gain insight into the underlying mechanisms of the condition, 32 adults attended a virtual focus group to describe their sound-induced pain.
View Article and Find Full Text PDFEffect of remimazolam on oxygen reserve compared with propofol during upper gastrointestinal endoscopy: Randomized controlled study.
Dig Endosc
November 2024
Department of Gastroenterology and Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Objectives: Propofol is commonly used for endoscopic sedation. However, it can induce adverse hemodynamic effects. Remimazolam is known to have a fast onset and short duration comparable to that of propofol, but with fewer effects on hemodynamics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!