Jet-lag and day-time sleepiness cannot be avoided in transmeridian operations, because work hours of aircrews interfere with the circadian system through irregular work-rest schedules and rapid time-zone transitions. Although the primary cause of accidents is usually the human factor, jet lag and sleepiness have seldom been officially identified as causes of inadequate functioning in the cockpit. However, research clearly indicates that flights at night and/or across time zones will impair performance and reduce safety. Research on countermeasures have focused on on-board napping, crew augmentation, behavioural strategies against jet-lag, light treatment and melatonin administration. Regrettably, scientific knowledge has been successfully transmitted to only a very few national authorities responsible for work hours of aircrews.
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http://dx.doi.org/10.1111/j.1365-2869.1995.tb00223.x | DOI Listing |
Handb Clin Neurol
January 2025
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States. Electronic address:
The nonimage-forming effects of light are pivotal in regulating cognitive functions, including alertness, sustained attention, and higher-order cognitive processes. These cognitive domains are deeply influenced by the sleep-wake cycle, which are governed by two key processes: the homeostatic process, which builds sleep pressure during wakefulness, and the circadian process, which aligns with environmental light cues to regulate wakefulness and sleep. When these processes fall out of sync-a condition known as circadian misalignment-alertness, sustained attention, and cognitive performance can suffer significantly.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Thrombosis and Hemostasis Unit, Rambam Health Care Campus, Haifa 3109601, Israel.
Circadian misalignment, due to shiftwork and/or individual chronotype and/or social jetlag (SJL), quantified as the difference between internal and social timing, may contribute to cardiovascular disease. Markers of endothelial dysfunction and activation of the coagulation system may predict cardiovascular pathology. The present study aim was to investigate the effects of shift work, SJL, and chronotype on endothelial function and coagulation parameters.
View Article and Find Full Text PDFChildren (Basel)
December 2024
School of Medicine, Kumamoto University, Kumamoto 860-8556, Japan.
Sleep disorders in children have a negative impact on mental and physical development, and a lack of sleep is one of the most important problems in infancy. At the age when naps are commonly accepted, the judgment of whether the amount of sleep is adequate has been based on the total amount of sleep per day. In other words, the idea is that even if the amount of sleep at night is insufficient, it is not considered insufficient if it is compensated for by taking a long nap or sleeping late on weekend mornings.
View Article and Find Full Text PDFACS Appl Bio Mater
January 2025
Hospital of Stomatology, Guanghua School of Stomatology, Guangzhou 510050, China.
Circadian rhythm disruption, commonly caused by factors such as jet lag and shift work, is increasingly recognized as a critical factor impairing wound healing. Although melatonin is known to regulate circadian rhythms and has potential in wound repair, its clinical application is limited by low bioavailability. To address these challenges, we developed an alginate-based dual-network hydrogel as a delivery system for melatonin, ensuring its stable and sustained release at the wound site.
View Article and Find Full Text PDFAm J Hum Biol
January 2025
One Health Research Group, Universidad de Las Américas, Quito, Ecuador.
Background: The misalignment of sleeping times during weekdays/weekends (i.e., social jetlag) is particularly common among adolescents and plausibly associated with their physical fitness.
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