The acute-toxic-class method (ATC) is an alternative to the classical LD&inf50; test. Four substances were tested with an ATC testing procedure. The results were compared with LD&inf50; data obtained from the literature. Great importance was attached to the observations of toxic signs following administration. The results of this study have shown that the ATC method allows allocation to toxicity classes in the same manner as on the basis of the classical LD&inf50; tests. The ATC method uses fewer animals and yields the same information on toxic signs. Introducing the ATC method into the quality system allows estimating the acute oral toxicity of chemicals according to the Organisation for Economic Cooperation and Development (OECD; OECD, 1992, 1996).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10803548.1998.11076384 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Parental precarious employment and the mental health of adolescents: a Swedish registry study.
Scand J Work Environ Health
January 2025
Department of Sociology and Political Science, Norwegian University of Science and Technology, postbox 8900, Torgarden, 7491 Trondheim, Norway.
Objective: This study investigates the association between parental precarious employment (PE) and the mental health of their adolescent children, with a particular focus on how the association differs based on whether the mother or father is in PE.
Methods: This register-based study used the Swedish Work, Illness, and Labor-market Participation (SWIP) cohort. A sample of 117 437 children aged 16 years at baseline (2005) were followed up until 2009 (the year they turned 20).
Assessment of the magnitude, economic impact, and factors associated with expired veterinary pharmaceuticals in animal health facilities in South Wollo, Ethiopia.
Front Vet Sci
January 2025
Department of Veterinary Pathobiology, College of Veterinary Medicine and Animal Sciences, University of Gondar, Gondar, Ethiopia.
Background: The issue of veterinary pharmaceutical expiration is a significant concern in animal health facilities globally. The existence of veterinary pharmaceutical expiration can be mainly associated with inadequate inventory control, store management, and a lack of effective pharmaceutical regulatory policies and guidelines. Hence, the study aimed to evaluate expired veterinary pharmaceuticals' scope, economic impact, and contributing factors.
View Article and Find Full Text PDFMachine learning-based prognostic model for patients with anaplastic thyroid carcinoma.
Discov Oncol
January 2025
Department of Thyroid Breast Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Objective: Despite the identification of various prognostic factors for anaplastic thyroid carcinoma (ATC) patients over the years, a precise prognostic tool for these patients is still lacking. This study aimed to develop and validate a prognostic model for predicting survival outcomes for ATC patients using random survival forests (RSF), a machine learning algorithm.
Methods: A total of 1222 ATC patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and randomly divided into a training set of 855 patients and a validation set of 367 patients.
Introduction: Individual case reports are essential to identify and assess previously unknown adverse effects of medicines. On these reports, information on adverse events (AEs) and drugs are encoded in hierarchical terminologies. Encoding differences may hinder the retrieval and analysis of clinically related reports relevant to a topic of interest.
View Article and Find Full Text PDFDrug interactions in patients with alcohol use disorder: results from a real-world study on an addiction-specific ward.
Ther Adv Drug Saf
January 2025
Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
Background: The majority of patients with alcohol use disorder (AUD) regularly take medication. Alcohol interacts negatively with many commonly prescribed drugs. However, little is known about the characteristics and frequency of potential alcohol-medication and drug-drug interactions in patients with AUD.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!