The authors describe a case of abdominal angiostrongyliasis in an adult patient presenting acute abdominal pain caused by jejunal perforation. The case was unusual, as this affliction habitually involves the terminal ileum, appendix, cecum or ascending colon. The disease is caused by the nematode Angiostrongylus costaricensis, whose definitive hosts are forest rodents while snails and slugs are its intermediate hosts. Infection in humans is accidental and occurs via the ingestion of snail or slug mucoid secretions found on vegetables, or by direct contact with the mucus. Abdominal angiostrongyliasis is clinically characterized by prolonged fever, anorexia, abdominal pain in the right-lower quadrant, and peripheral blood eosinophilia. Although usually of a benign nature, its course may evolve to more complicated forms such as intestinal obstruction or perforation likely to require a surgical approach. Currently, no efficient medication for the treatment of abdominal angiostrongyliasis is known to be available. In this study, the authors provide a review on the subject, considering its etiopathogeny, clinical picture, diagnosis and treatment.
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http://dx.doi.org/10.1590/s0036-46651999000500010 | DOI Listing |
Adv Sci (Weinh)
January 2025
Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong, 510080, China.
Angiostrongylus cantonensis (AC) is the leading cause of eosinophilic meningoencephalitis worldwide. The neuroimmune interactions between peripheral and central immune systems in angiostrongyliasis remain unclear. In this study, significant infiltration of eosinophils, myeloid cells, macrophages, neutrophils, and Ly6C monocytes is observed in the brains of AC-infected mice, with macrophages being the most abundant.
View Article and Find Full Text PDFVet Radiol Ultrasound
January 2025
IVC Evidensia GmbH, Hofheim Animal Hospital, Hofheim am Taunus, Germany.
A 2-year-old intact male Airedale Terrier was presented with a sudden onset of neurological signs, manifesting as hemiparesis, which were neuroanatomically localized to the brain. Initial bloodwork conducted by the local veterinarian indicated decreased levels of von Willebrand factor, and further examination showed an extended buccal mucosal bleeding time. MRI revealed a substantial hemorrhage within the right parietal lobe, while CT exhibited a mixed pulmonary pattern with unstructured interstitial, peribronchial, and alveolar components, presumably associated with larval migration and pulmonary microhemorrhages.
View Article and Find Full Text PDFJ Pediatric Infect Dis Soc
December 2024
Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis has been reported in several southern U.S. states and Hawai'i.
View Article and Find Full Text PDFParasitol Int
October 2023
Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien, Taiwan.
A significant complication of angiostrongyliasis remains eosinophilic meningoencephalitis, leading to patients' neurological deterioration, cerebral palsy, and respiratory changes, resulting in death. Clinically, A. cantonensis-infected patients sometimes showed decreased CSF glucose levels.
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