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Early antibiotics administration reduces mortality in sepsis patients in tertiary care hospital.
BMC Infect Dis
January 2025
Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.
Introduction: Early antibiotic administration is one of the core treatments of sepsis which associated with reduced mortality rate. However, the appropriate timing of antibiotics remains a controversial issue, especially in patients without septic shock. Here, we reported the outcomes of early antibiotic administration within one hour from the time of infection suspicion in a tertiary care hospital.
View Article and Find Full Text PDFThe Value and Importance of a Professional Ethical Code for Medicines Development: IFAPP International Ethics Framework.
Pharmaceut Med
January 2025
Pharmaceutical Medicine, Dover Heights, Sydney, NSW, Australia.
Pharmaceutical medicine professionals have to face many ethical problems during the entire life span of new medicines extending from animal studies to broad clinical practice. The primary aim of the general ethical principles governing research conducted in humans is to diminish the physical and psychological burdens of the participants in human drug studies but overlooks many additional social and ethical problems faced by medicine developers. These arise mainly at the interface connecting the profit-oriented pharmaceutical industry and the healthcare-centered medical profession cooperating in medicines development.
View Article and Find Full Text PDFIndependent aggregation in the nordic day-ahead market: What is the welfare impact of socializing supplier compensation payments?
Heliyon
January 2025
Institute of Power Engineering, Riga Technical University, Azenes iela 12/1, Riga, LV, 1048, Latvia.
This paper addresses the participation of independent aggregators (IAs) for demand response (DR) in European electricity markets. An IA is an aggregator trading the flexibility of consumers of which it is not the electricity supplier. Particularly, we focus on the controversial issue of a compensation payment from the IA to the supplier for energy sourcing.
View Article and Find Full Text PDFApplying Rawls' Theory of Public Reason to Controversies over Parental Surrogacy.
Camb Q Healthc Ethics
January 2025
Parental surrogacy remains a highly controversial issue in contemporary ethics with considerable variation in the legal approaches of different jurisdictions. Finding a societal consensus on the issue remains highly elusive. John Rawls' theory of public reason, first developed in his (1971), offers a unifying model of political discourse and engagement that enables reasonable citizens to accept policies that they do not necessarily support at a personal level.
View Article and Find Full Text PDFSynthesis of honeycomb-like citric acid-crosslinked chitosan hydrogel beads (cCHBs): Insight into structural characteristics of Cu(II)-loaded cCHBs (cCHBs-Cu(II)).
Int J Biol Macromol
January 2025
Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment (MEE), Nanjing 210042, China.
To date, it has been regarded as one of the most challenging issues to construct novel adsorbents possessing excellent adsorption performance toward heavy metals including copper ions (Cu(II)). Especially, it is controversy about the structural characteristics of chitosan-based adsorbents adsorbed with Cu(II) ions, which could function as new adsorbents. In this study, we adopt a freeze-drying process to synthesize honeycomb-like chitosan hydrogel beads crosslinked with citric acid (cCHBs), further characterize the microstructures of cCHBs and eventually reveal the thermodynamics equations for the removal of target Cu(II).
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