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Bacteriophage Therapy as a Promising Alternative for Antibiotic-Resistant : Advances and Challenges.
Antibiotics (Basel)
November 2024
Clinical Microbiology Department, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, 28040 Madrid, Spain.
is a Gram-positive bacterium increasingly identified as a critical nosocomial pathogen that poses significant treatment challenges due to its resistance to multiple antibiotics, particularly vancomycin-resistant (VRE) strains. The urgent need for alternative therapeutic strategies has renewed interest in bacteriophage (phage) therapy, given phages specificity and bactericidal potential. This review explores the advancements in phage therapy against antibiotic-resistant , including phage morphological diversity, genomic characteristics, and infection mechanisms.
View Article and Find Full Text PDFDemographic and pathogen characteristics of incident bacterial meningitis in infants in South Africa: A cohort study.
PLoS One
September 2024
School of Public Health, Division of Epidemiology and biostatistics, University of the Witwatersrand, Johannesburg, South Africa.
Article Synopsis
- Bacterial meningitis poses a significant health risk in South Africa, particularly in children under 1 year old, with a high case fatality rate of 37% and a focus on incidents from 2014 to 2018 during vaccination program implementations.
- A cohort study analyzing routine laboratory data identified 3,575 confirmed cases of bacterial meningitis, with the majority occurring in infants under 28 days old, predominantly affecting males and concentrated in Gauteng Province.
- The most frequently detected pathogens included Acinetobacter baumannii, Klebsiella pneumoniae, and group B streptococcus, with A. baumannii showing the highest incidence risk in 2018 among children under 1 year.
Best Practices for Identifying Hospitalized Lower Respiratory Tract Infections Using Administrative Data: A Systematic Literature Review of Validation Studies.
Infect Dis Ther
April 2024
Scientific Affairs, Older Adult RSV Vaccine Program, Global Medical Development Scientific and Clinical Affairs, Pfizer Vaccines, Pfizer Inc., 9 Riverwalk, Citywest Business Campus, Dublin 24, Dublin, Ireland.
Introduction: Estimating the burden of lower respiratory tract infections (LRTIs) increasingly relies on administrative databases using International Classification of Diseases (ICD) codes, but no standard methodology exists. We defined best practices for ICD-based algorithms that estimate LRTI incidence in adults.
Methods: We conducted a systematic review of validation studies assessing the use of ICD code-based algorithms to identify hospitalized LRTIs in adults, published in Medline, EMBASE, and LILACS between January 1996 and January 2022, according to PRISMA guidelines.
Antimicrobial resistance (AMR) threatens human, animal, and environmental health. Acknowledging the urgency of addressing AMR, an opportunity exists to extend AMR action-focused research beyond the confines of an isolated biomedical paradigm. An AMR learning system, AMR-X, envisions a national network of health systems creating and applying optimal use of antimicrobials on the basis of their data collected from the delivery of routine clinical care.
View Article and Find Full Text PDFInfection Diagnosed by tNGS in a Lady with Lymphadenopathy.
Infect Drug Resist
July 2023
Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
We report a case of a 34-year-old lady with multiple joint pain. Autoimmune diseases were considered first with a positive result of anti-Ro antibody and her right knee joint cavity effusion. Later, bilateral interstitial changes in her lungs and mediastinal lymphadenopathy were found after chest CT scanning.
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