The mammalian corneal stroma has some intriguing features related to its lamellar structure. OPTICAL LAMINATION: Stromal sections under the polarizing microscope show birefringent bands that are about 5 times less numerous than the collagenous lamellae seen in transmission electron microscopy (TEM). Scattered light reveals similar laminae in the intact fresh tissue. COHESION: Very thin sections of stroma do not fall apart under water, indicating the presence of a structural framework that holds the collagen fibrils together. SHEAR DISTORTION: The stroma shears very readily in its plane; the shear amplitude increases and then decreases as the tissue hydrates. This suggests that the structural framework is coiled at physiological hydration and can expand about 10 times. FOLDING: When the stroma swells, the lamellae are thrown into waves that lie both in the plane of and perpendicular to its surface. It is difficult to understand how the latter are packed.
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