Background: Lung volume reduction surgery (LVRS) improves dyspnea, pulmonary function, and quality of life in selected patients with severe emphysema. We investigated the role of emphysema morphology in 37 patients as an outcome predictor for up to 2 years after operation.
Methods: Patients selected for bilateral thoracoscopic LVRS were divided, according to a simplified emphysema morphology classification, into three groups (homogeneous, moderately heterogeneous, and markedly heterogeneous) based on a preoperative chest computed tomogram. Pulmonary function, walking distance, and dyspnea were assessed.
Results: Functional improvement after LVRS was best in markedly heterogeneous emphysema with an increase from preoperative forced expiratory volume in 1 second of 31% +/- 2% (mean +/- standard error of the mean) to 52% +/- 4% of predicted postoperatively. It was significantly higher than in homogeneous emphysema (from 26% +/- 1% to 38% +/- 2% predicted) and in intermediately heterogeneous emphysema (from 29% +/- 2% to 44% +/- 45% predicted). At 24 months postoperatively, forced expiratory volume in 1 second and dyspnea score continued to be significantly better than preoperative levels in all three morphologic groups. The survival rate was highest in patients with markedly heterogeneous emphysema.
Conclusions: Functional and subjective improvements were maintained after LVRS for at least 24 months in patients with heterogeneous or homogeneous emphysema type.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0003-4975(99)00990-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fully Atomistic Molecular Dynamics Simulation of Ice Nucleation Near an Antifreeze Protein.
J Am Chem Soc
January 2025
Department of Materials Science and Engineering, City University of Hong Kong, Hong Kong, Kowloon 999077, China.
Heterogeneous ice nucleation is a widespread phenomenon in nature. Despite extensive research on ice nucleation near biological antifreeze proteins, a probe for ice nucleation and growth processes at the atomic level is still lacking. Herein, we present simulation evidence of the heterogeneous ice nucleation process on the ice-binding surface (IBS) of the antifreeze protein (TmAFP).
View Article and Find Full Text PDFPopulation Size Estimation of Men Who Have Sex With Men in Low- and Middle-Income Countries: Google Trends Analysis.
JMIR Public Health Surveill
January 2025
Division of Global HIV and TB, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA, 30322, United States, 1 8103383534.
Background: Population size estimation (PSE) for key populations is needed to inform HIV programming and policy.
Objective: This study aimed to examine the utility of applying a recently proposed method using Google Trend (GT) internet search data to generate PSE (Google Trends Population Size Estimate [GTPSE]) for men who have sex with men (MSM) in 54 countries in Africa, Asia, the Americas, and Europe.
Methods: We examined GT relative search volumes (representing the relative internet search frequency of specific search terms) for "porn" and, as a comparator term, "gay porn" for the year 2020.
Entropy-based methods for formulating bottom-up ultra-coarse-grained models.
J Chem Phys
January 2025
Department of Chemistry, Chicago Center for Theoretical Chemistry, James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, USA.
Bottom-up coarse-grained (CG) modeling is an effective means of bypassing the limited spatiotemporal scales of conventional atomistic molecular dynamics while retaining essential information from the atomistic model. A central challenge in CG modeling is the trade-off between accuracy and efficiency, as the inclusion of often pivotal many-body interaction terms in the CG force-field renders simulation markedly slower than simple pairwise models. The Ultra Coarse-Graining (UCG) method incorporates many-body terms through discrete internal state variables that modulate the CG force-field according to, e.
View Article and Find Full Text PDFExploring synergistic evolution of carbon emissions and air pollutants and spatiotemporal heterogeneity of influencing factors in Chinese cities.
Sci Rep
January 2025
School of Management, Xi'an University of Architecture and Technology, Xi'an, 710055, China.
The acceleration of urbanization has significantly exacerbated climate change due to excessive anthropogenic carbon emissions and air pollutants. Based on data from 281 prefecture-level cities in China between 2015 and 2021. The spatiotemporal co-evolution of urban carbon emissions and air pollutants was analyzed through map visualization and kernel density estimation, revealing non-equilibrium and heterogeneity.
View Article and Find Full Text PDFHeterogeneous zonal impacts of climate change on a wide hyperendemic area of human and animal fascioliasis assessed within a One Health action for prevention and control.
PLoS Negl Trop Dis
January 2025
Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Burjassot, Valencia, Spain.
The Northern Bolivian Altiplano is the fascioliasis endemic area where the highest prevalences and intensities in humans have been recorded. In this hyperendemic area of human fascioliasis, the disease is caused only by Fasciola hepatica and transmitted by Galba truncatula, the sole lymnaeid species present in the area. When analysing the link between global warning and the recently reported geographical spread of lymnaeid populations to out-border localities, a marked heterogeneous climatic change was found throughout the endemic area.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!