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Exploring the impact of RPN1 on tumorigenesis and immune response in cancer.
FASEB J
March 2025
Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, Hunan, China.
The ribophorin family, including RPN1, has been associated with tumor progression, but its specific role in pan-cancer dynamics remains unclear. Using data from TCGA, GTEx, and Ualcan databases, we investigated the relationship of RPN1 with prognosis, genomic alterations, and epigenetic modifications across various cancers. Differential analysis revealed elevated RPN1 expression in multiple cancer types, indicating a potential prognostic value.
View Article and Find Full Text PDFOpioid withdrawal syndrome induced by naldemedine administration in a cancer patient without brain metastasis.
Palliat Support Care
March 2025
Departments of Psycho-oncology, Saitama Medical University International Medical Center, Saitama, Japan.
Objectives: Naldemedine is a peripherally acting μ-opioid receptor antagonist used to treat opioid-induced constipation. As this drug does not cross the blood-brain barrier, it is believed that patients without brain metastases do not experience opioid withdrawal symptoms.
Methods: Here, we experienced a case in which a cancer patient without brain metastasis presented with anxiety and restlessness that was severe enough to interfere with daily life.
Prurigo pigmentosa following laparoscopic sleeve gastrectomy: a case report.
J Surg Case Rep
March 2025
Department of General Surgery, Prince Sultan Military Medical City, Riyadh Makkah Al Mukarramah Road, As Sulimaniyah, Riyadh, 12233, Saudi Arabia.
Prurigo pigmentosa (PP) is a rare dermatological condition with an unclear, often idiopathic etiology, but recent evidence points to a potential link between the disease and metabolic changes, particularly those associated with ketosis. It typically presents as a pruritic, erythematous rash, mainly affecting the trunk and neck, and often features hyperpigmented macules and plaques. The onset of PP has been associated with various factors, including fasting, dieting, and certain metabolic disorders.
View Article and Find Full Text PDFSignificant association between systemic inflammation response index and prognosis in patients with urological malignancies.
Front Immunol
March 2025
Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Background: The systemic inflammation response index (SIRI) as an immune marker, is associated with prognosis of urological malignancies(UM). However, the conclusion remains controversial. Therefore, the objective of this study was to conduct a meta-analysis to comprehensively evaluate the predictive value of SIRI in patients with UM.
View Article and Find Full Text PDFThe clinical significance of T-cell regulation in hypertension treatment.
Front Immunol
March 2025
Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, Hubei, China.
Hypertension, a globally prevalent condition, is closely associated with T cell-mediated inflammatory responses. Studies have shown that T cells, by secreting pro-inflammatory cytokines such as interferon-gamma (IFN-γ), Interleukin-17 (IL-17), and Tumor necrosis factor-alpha (TNF-α), directly lead to vascular dysfunction and elevated blood pressure. The activation of Th1 and Th17 cell subsets, along with the dysfunction of regulatory T cells (Tregs), is a critical mechanism in the onset and progression of hypertension.
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