The aim of this study was to determine which of the one-dimensional acceleration signals best correlates with the heart rate under the conditions of daily activities, or whether such correlation is shown by three-dimensional acceleration signals. A commercially available biosignal system (ZAK, Germany) was used to record electrographic data and acceleration caused by body movements in the three directions vertical, sagittal and lateral. The evaluation was performed on 12 young healthy volunteers and 4 elderly volunteers with cardiovascular disorders but adequate chronotropic function. Informed consent was given by all participants. Activity signals and heart rate were recorded while walking under two different conditions. For analysis, the pathways were divided into segments with different gradients. All the acceleration signals were analysed statistically and temporally with regard to peak-to-peak value, root mean square value, and step frequency by means of cross correlation. Both statistical and temporal analysis showed that the correlation of heart rate and all one-dimensional acceleration signals and the three-dimensional acceleration signal was relatively low (r < or = 0.6). Walking uphill even showed a negative correlation between acceleration signals and heart rate. Despite the widespread use of activity-controlled pacemakers, the correlation between heart rate and acceleration signals is not satisfactory.
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http://dx.doi.org/10.1515/bmte.1999.44.10.260 | DOI Listing |
Bioact Mater
May 2025
State Key Laboratory of New Ceramics and Fine Processing, Key Laboratory of Advanced Materials, School of Materials Science and Engineering, Tsinghua University, 100084, Beijing, China.
Wound healing in chronic diabetic patients remains challenging due to the multiple types of cellular dysfunction and the impairment of multidimensional microenvironments. The physical signals of structural anisotropy offer significant potential for orchestrating multicellular regulation through physical contact and cellular mechanosensing pathways, irrespective of cell type. In this study, we developed a highly oriented anisotropic nanofiber hydrogel designed to provide directional guidance for cellular extension and cytoskeletal organization, thereby achieving pronounced multicellular modulation, including shape-induced polarization of macrophages, morphogenetic maturation of Schwann cells, oriented extracellular matrix (ECM) deposition by fibroblasts, and enhanced vascularization by endothelial cells.
View Article and Find Full Text PDFMedical imaging systems are commonly assessed and optimized by the use of objective measures of image quality (IQ). The performance of the ideal observer (IO) acting on imaging measurements has long been advocated as a figure-of-merit to guide the optimization of imaging systems. For computed imaging systems, the performance of the IO acting on imaging measurements also sets an upper bound on task-performance that no image reconstruction method can transcend.
View Article and Find Full Text PDFDiabetes
January 2025
Department of Geriatrics, Peking University Shenzhen Hospital, Shenzhen, China.
Insulin resistance, a hallmark of type 2 diabetes, accelerates muscle breakdown and impairs energy metabolism. However, the role of Ubiquitin Specific Peptidase 2 (USP2), a key regulator of insulin resistance, in sarcopenia remains unclear. Peroxisome proliferator activated receptor γ (PPARγ) plays a critical role in regulating muscle atrophy.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
February 2025
Departments of Physics, Cell Biology and Biochemistry, Emory University, Atlanta, GA 30322.
Cellular actin networks exhibit distinct assembly and disassembly dynamics, primarily driven by multicomponent reactions occurring at the two ends of actin filaments. While barbed ends are recognized as the hotspot for polymerization, depolymerization is predominantly associated with pointed ends. Consequently, mechanisms promoting barbed-end depolymerization have received relatively little attention.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
Department of Translational & Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India.
The area of wound healing presents a promising field of interest for clinicians as well as the scientific community. A major concern for physicians is the rising number of elderly people suffering from diabetes, leprosy, tuberculosis and the associated chronic wounds. While traditional therapies target basic wound care, innovative strategies that accelerate wound healing are needed.
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