Kita is a health district of Mali, a leprosy-endemic country in West Africa. We conducted a comparative study of passive and active case finding of leprosy in this district in 1997. In May and June, a mobile team realized active case finding by visiting 32 villages of more than 1000 inhabitants. For 12 months, peripheral health center nurses did passive detection after information and education sessions about the signs of leprosy in the other 37 main villages of Kita. The active detection rate (4.31 per 10,000) was threefold higher than the passive rate (1.5 per 10,000) and allowed us to find earlier cases of leprosy. Active case finding identified children and single-lesion disease; the passive method did not. Cost for finding a new case was estimated at 72 US$ by mobile team detection and 36 US$ by passive case finding. Although the active method looked more expensive than the passive one, it was the only effective strategy to detect leprosy patients in remote and difficult-to-access areas. Based upon the results of the study, a flow chart is proposed for the choice of case-finding method when designing a leprosy elimination program.
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J Cancer Res Clin Oncol
January 2025
Sarcoma Unit, Department of Surgery, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
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Faculty of Medicine, Department of Emergency Medicine, Akdeniz University, Antalya, Turkey.
Patients presenting with suspected acute coronary syndrome (ACS) in the emergency department (ED) require rapid and accurate electrocardiographic (ECG) evaluation. This study aims to assess conventional ECG markers for diagnosing non-ST-elevation ACS (NSTE-ACS) in patients with chest discomfort and right bundle branch block (RBBB). A nested case-control design was employed to compare patients with RBBB admitted to the ED for suspected cardiac ischemia, focusing on those who developed NSTE-ACS versus those who did not.
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Postgraduate Program in Biochemistry, Federal University of Espírito Santo (UFES), Vitória, Espírito Santo, Brazil.
Asthma is a complex disease with varied clinical manifestations resulting from the interaction between environmental and genetic factors. While chronic airway inflammation and hyperresponsiveness are central features, the etiology of asthma is multifaceted, leading to a diversity of phenotypes and endotypes. Although most research into the genetics of asthma focused on the analysis of single nucleotide polymorphisms (SNPs), studies highlight the importance of structural variations, such as copy number variations (CNVs), in the inheritance of complex characteristics, but their role has not yet been fully elucidated in asthma.
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Department of Geography, Rampurhat College, PO-Rampurhat, Dist-Birbhum, 731224, India.
In fluvial environments, the shifting of river channels and bank erosion are frequently caused by both natural and anthropogenic factors. Riverine hazards like bank erosion and course alterations offer severe issues to the riparian villages along the lower basin of the Tista River in India, which substantially influence the livelihoods of inhabitants living there. This research addressed river channel shifting tendency and identified major bank erosion-prone villages along the lower course of the Tista River and challenges to the livelihoods of the riparian people.
View Article and Find Full Text PDFSci Rep
January 2025
College of Architecture and Urban Planning, Guizhou University, Guiyang, 550025, China.
Karst small towns globally face challenges due to limited disaster-resilient resources, making it difficult to handle increasingly severe disaster environments. Improving the efficiency of disaster-resilient resource utilization and maintaining a tight balance state of disaster-resilient resources (TBS) are crucial for enhancing disaster adaptability and resilience. This study used urban and disaster data from a representative karst region in China (2017-2021) to conduct a quantitative analysis of TBS in karst small towns, exploring the mechanisms and interactions within this state and identifying obstacle factors.
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