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Hepatoblastoma in a 13-Month-old Male With Oculofaciocardiodental Syndrome.
J Pediatr Hematol Oncol
January 2025
Division of Haematology/Oncology, Department of Pediatrics, Children's Hospital, London Health Sciences Centre, London, ON, Canada.
Background: Oculofaciocardiodental (OFCD) syndrome is an X-linked dominant condition that is typically lethal in males.
Observations: A 13-month-old male patient with OFCD syndrome presented with hepatoblastoma. He received chemotherapy per standard of care and had a surgical resection with few complications.
Characteristics of patients with liver tumors deemed ineligible for enrollment on Children's Oncology Group trial AHEP1531: An opportunity to expand inclusion criteria and improve outcome.
Pediatr Blood Cancer
January 2025
Division of Pediatric Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Background: Specific patients with hepatoblastoma (HB) and hepatocellular carcinoma (HCC) do not meet eligibility criteria for Children's Oncology Group (COG) trials, limiting an understanding of how comorbidities affect the outcome. We define such a population for future-focused care improvements.
Methods: A questionnaire was sent to COG institutional principal investigators to obtain anonymized data regarding patients with a liver tumor diagnosis not enrolled on AHEP1531 due to ineligibility by trial criteria or other reasons (excluding parent/patient preference).
A case report of congenital hepatoblastoma.
Int J Surg Case Rep
November 2024
Department of Surgical Oncology, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, People's Republic of China. Electronic address:
Introduction: Reports of congenital hepatoblastoma are rare, and there is limited experience in its management.
Case Presentation: We present a challenging case of congenital hepatoblastoma that was large at the time of presentation, occupying the first and second hepatic portals and deemed inoperable. Although liver tumors was detected in the child during the mother's pregnancy, the initial diagnosis was hepatic hemangioma.
Clinical Characteristics and Outcomes of Neonatal Hepatoblastoma: A Single Center Study.
J Pediatr Surg
November 2024
Department of General Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address:
Article Synopsis
- Neonatal hepatoblastoma (HB), diagnosed within the first month of life, presents unique challenges in treatment and prognosis, prompting a study to analyze its diagnosis, treatment, and outcomes at a single center.
- The study observed 79 patients under one year old, identifying 14 with neonatal HB, which exhibited distinct clinical features such as smaller tumor size and higher tumor grades compared to non-neonatal cases, along with significantly elevated AFP levels.
- Results indicated a 100% three-year survival rate and event-free survival for neonatal HB patients, demonstrating that combined treatment strategies of surgery and chemotherapy can be highly effective, warranting further research in larger populations.
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