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Alzheimers Dement
December 2024
SAIHST, Sungkyunkwan University, Seoul, Korea, Republic of (South).
Background: Brain diseases complexity have necessitated advanced research platforms for better understanding, treatment, and prevention strategies. However, existing brain disease registries face limitations such as incomplete variable sets, lack of standardization, insufficient linkage to external databases, absence of integrated platforms for comprehensive data collection, and lack of continuity. To address these challenges, the Korea National Institute of Health initiated the Brain disease Research Infrastructure for Data Gathering and Exploration (BRIDGE), a national prospective platform designed to overcome the shortcomings of current registries.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
BioXcel Therapeutics, New Haven, CT, USA.
Background: BXCL501, a sublingual film formulation of dexmedetomidine, a highly selective α2 adrenoceptor agonist, is currently being studied for the acute treatment of agitation associated with dementia.
Method: This was a Phase 1b/2 study assessing efficacy and tolerability of BXCL501 for treatment of acute agitation associated with dementia. Subjects were randomized to active treatment with BXCL501 (30, 40, or 60µg) or placebo.
Support for the management of cognitive and autonomic features of Lewy body dementia (LBD) is offered in detail in this presentation. The US Based Diamond Lewy Cognitive Symptoms management document presents the unique cognitive profile of LBD with general principles for addressing these features along with detailed guidance in the use of cholinesterase inhibitors and Memantine. The US Based Diamond Lewy Autonomic Symptoms management document addresses the management of common autonomic symptoms including urinary dysfunction, male sexual dysfunction, excessive sweating, constipation, sialorrhea, gastroparesis and orthostatic hypotension in LBD.
View Article and Find Full Text PDFEtiological factors and management of vertigo - a retrospective study.
Med J Malaysia
January 2025
Department of ENT - HNS, Saveetha Medical College Hospital, Thandalam, Chennai, India.
Introduction: Vertigo and dizziness are symptoms of various underlying conditions, ranging from benign to severe, affecting up to 40% of adults. Understanding the etiological factors and demographic characteristics associated with these symptoms is crucial for improving diagnostic accuracy and management. This study aims to identify the etiological factors contributing to vertigo and dizziness in a clinical setting and assess the effectiveness of treatment strategies.
View Article and Find Full Text PDFA randomized comparative study to prevent supine hypotension syndrome in pregnant females undergoing LSCS after giving spinal anesthesia using a wedge and novel 3D printed uterine displacement device.
Med J Malaysia
January 2025
Department of Anesthesia, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, India.
Introduction: Pregnancy induces physiological changes, including alterations in cardiovascular dynamics, predisposing pregnant women to supine hypotension syndrome (SHS) during lower-segment cesarean section (LSCS) under spinal anesthesia. Various methods, including manual displacement of the uterus and use of wedges or cushions, have been proposed to prevent SHS, but their effectiveness remains variable. This study aimed to compare the efficacy of a novel 3D-printed uterine displacement device with that of a traditional wedge in preventing SHS during LSCS after spinal anesthesia.
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