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Unstable pathogen profile in spotted seal (Phoca largha) gut microbiota and limited turnover with habitat microbiome.
Int Microbiol
November 2024
Dalian Key Laboratory of Conservation Biology for Endangered Marine Mammals, Liaoning Ocean and Fisheries Science Research Institute, Dalian, 116023, Liaoning, China.
Article Synopsis
- - Monitoring the gut microbiota of sentinel species like spotted seals is crucial for understanding marine mammal health and ecological impacts, as highlighted in this study using PacBio technology to sequence bacteria from seal feces and their habitats.
- - The findings showed that while wild and captive seals have similar levels of pathogens, wild seals exhibited more variability in pathogen profiles, indicating a higher disease risk for some individuals.
- - Additionally, the study revealed that spotted seals have less diverse gut microbiota compared to their habitat, with certain bacterial groups (Firmicutes for seals, Proteobacteria for habitats) dominating, and a low microbial turnover rate between them (less than 0.1%).
A comparison of adult and pediatric guidelines for the management of blunt splenic trauma.
Asian J Surg
November 2024
Department of Traumatology, John Hunter Hospital, Newcastle, New South Wales, Australia. Electronic address:
Article Synopsis
- The management of blunt splenic trauma differs between children and adults, influenced by guidelines from organizations like the APSA and WTA, particularly regarding treatment methods like splenectomy and angioembolization.* -
- A comparison of the 2023 guidelines revealed that while initial resuscitation is standard, the management strategies diverge: adults' care is guided by both CT findings and hemodynamic status, while children's care relies solely on hemodynamics.* -
- Differences in ICU admission, follow-up protocols, and thromoprophylaxis use highlight the distinct approaches for each age group, suggesting a need for unified guidelines that cater to the specific needs of both children and adults.*
Longitudinal stability of molecular endotypes of knee osteoarthritis patients.
Osteoarthritis Cartilage
January 2025
Nordic Bioscience, Herlev, Denmark. Electronic address:
Objective: To assess the longitudinal stability of biomarker-based molecular endotypes of knee osteoarthritis (KOA) participants from APPROACH and to evaluate the consistency of findings in an independent KOA population.
Methods: Nineteen biomarkers were measured longitudinally in 295 KOA participants from the APPROACH cohort. K-means clustering was used to identify the structural damage, inflammation, and low tissue turnover endotypes at the six-, 12-, and 24-month follow-ups.
Recent advances in proteomic analysis to study carotid artery plaques.
JVS Vasc Sci
August 2024
Division of Vascular and Endovascular Surgery, Mayo Clinic, Jacksonville, FL.
Objective: We sought to identify differentially expressed proteins in serum, plasma, and plaque samples of patients with carotid atherosclerotic lesions.
Methods: We performed a systematic review of the proteomic profile of serum, plasma, and plaque samples of patients with carotid artery disease. We included full-length peer-reviewed studies of adult humans and reported them using PRISMA guidelines.
Safety and procedural success of daycase-based endovascular procedures in lower extremity arteries of patients with peripheral artery disease: a systematic review and meta-analysis.
EClinicalMedicine
September 2024
Vascular Medicine Department, Surrey and Sussex Healthcare NHS Trust, Redhill, UK.
Background: Timely and economic provision of revascularisation procedures is a major healthcare need. We aimed to examine the safety and efficacy of daycase-based lower extremity endovascular revascularisation procedures in patients with peripheral artery disease.
Methods: In this systematic review and meta-analysis, we searched MEDLINE and Embase for studies from Jan 01, 2000 through Apr 01, 2024 reporting complications of lower limb endovascular revascularisation procedures with same-day discharge.
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