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In vivo assembly in tobacco cells to elucidate and engineer the biosynthesis of 4-hydroxydihydrocinnamaldehyde from Gloriosa superba.
Plant Cell Rep
September 2024
National Key Laboratory for Tropical Crops Breeding, Sanya, 572024, China.
This study described the biosynthesis of 4-hydroxydihydrocinnamaldehyde sharing with monolignol pathway and supplemented the biosynthesis of colchicine in G. superba, 4-hydroxydihydrocinnamaldehyde produced in tobacco BY2 cells provided an important stepstone. The precursor, 4-hydroxydihydrocinnamaldehyde (4-HDCA), participates in the biosynthesis of the carbon skeleton of colchicine, which is derived from L-phenylalanine.
View Article and Find Full Text PDFClinical Utility of Rilonacept for the Treatment of Recurrent Pericarditis: Design, Development, and Place in Therapy.
Drug Des Devel Ther
September 2024
First Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Recurrent pericarditis (RP) has been traditionally regarded as a "nightmare" for both clinicians and patients. Until approximately a decade ago, available treatments were thin on the ground with non-steroidal anti-inflammatory medications, glucocorticoids, colchicine, and classical immunosuppressants being the only options. The first important step in the tale of RP was the advent of colchicine in clinical practice, which has been shown to halve the rate of first and subsequent pericarditis recurrences.
View Article and Find Full Text PDFTransport of glycinin, the major soybean allergen, across intestinal epithelial IPEC-J2 cell monolayers.
J Anim Physiol Anim Nutr (Berl)
September 2024
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, PR China.
Soybean allergen entering the body is the initial step to trigger intestinal allergic response. However, it remains unclear how glycinin, the major soybean allergen, is transported through the intestinal mucosal barrier. The objective of this study was to elucidate the pathway and mechanism of glycinin hydrolysates transport through the intestinal epithelial barrier using IPEC-J2 cell model.
View Article and Find Full Text PDFImpact of the 2021 European Society for Cardiology prevention guideline's stepwise approach for cardiovascular risk factor treatment in patients with established atherosclerotic cardiovascular disease.
Eur J Prev Cardiol
April 2024
Department of Vascular Medicine, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands.
Article Synopsis
- The study evaluated the effectiveness of a stepwise approach for treating cardiovascular risk factors based on European guidelines in patients with established atherosclerotic cardiovascular disease (ASCVD).
- Researchers analyzed data from two large patient cohorts, identifying treatment goals focused on lowering LDL cholesterol and blood pressure, as well as promoting smoking cessation and various medication combinations.
- Results indicated that using intensified Step 2 treatment options significantly reduces residual cardiovascular risk, improving patient outcomes and potentially decreasing events per 1000 patients treated in different European risk regions.
Inflammatory Biomarkers and Stroke Subtype: An Important New Frontier.
Neurology
January 2024
From the Department of Neurology (S.C.), University of Maryland, Baltimore; and Department of Neurology & Stroke Center (G.M.D.M.), Kantonsspital St. Gallen, Switzerland.
Inflammation is an established pathway in the formation, growth, and rupture of atherosclerotic plaques. Inflammation is thus essential to the pathogenesis of coronary heart disease and some types of ischemic stroke. The benefit of anti-inflammatory therapies, such as colchicine and the anti-IL1β canakinumab, is proven in patients with coronary heart disease, yet it remains unproven for patients with ischemic stroke.
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