The complete genome sequence of the radiation-resistant bacterium Deinococcus radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (177,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284, 156 base pairs. Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of D. radiodurans to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified. Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147723PMC
http://dx.doi.org/10.1126/science.286.5444.1571DOI Listing

Publication Analysis

Top Keywords

base pairs
16
deinococcus radiodurans
12
genome sequence
8
bacterium deinococcus
8
dna damage
8
sequence radioresistant
4
radioresistant bacterium
4
radiodurans
4
radiodurans complete
4
complete genome
4

Similar Publications

A SPR aptamer sensor for mercury based on AuNPs@NaYF:Yb,Tm,Gd upconversion luminescent nanoparticles.

Anal Methods

November 2017

Anhui Key Laboratory of Chemo-Biosensing, Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China.

A new aptamer-based surface plasmon resonance (SPR) system has been designed to detect Hg that utilizes near-infrared (NIR)-to-NIR gold nanoparticle coated NaYF:Yb,Tm,Gd up-conversion nanoparticles (AuNPs@NaYF:Yb,Tm,Gd UCNPs) as probes. The AuNPs@NaYF:Yb,Tm,Gd UCNPs were prepared and excited by near-infrared light (980 nm) which emitted at a near-infrared wavelength (808 nm) using an inexpensive infrared continuous wave laser diode. The AuNPs@NaYF:Yb,Tm,Gd UCNPs were conjugated with Hg aptamers.

View Article and Find Full Text PDF

Na-concentration dependent conformational switch of oncogene RET G-quadruplex DNA in solution.

Int J Biol Macromol

January 2025

State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address:

Proto-oncogene RET is overexpressed in many cancers, and its expression level is positively related to the size and malignancy of the tumors. Effective inhibition of its overexpression can be used to potentially treat cancers. A guanine-rich GC-boxes (I-V) sequence in its promoter region folds into noncanonical G-quadruplex (G4) DNA structures, negatively regulating its expression by interactions with small molecules.

View Article and Find Full Text PDF

Isolation and characterization of a broad-spectrum bacteriophage against multi-drug resistant Escherichia coli from waterfowl field.

Poult Sci

January 2025

Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China; Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu 611130, PR China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, PR China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education, PR China. Electronic address:

Escherichia coli (E. coli) is a significant pathogen responsible for intestinal infections and foodborne diseases. The rise of antibiotic resistance poses a significant challenge to global public health.

View Article and Find Full Text PDF

Sequence analysis and genome organization of a new marafivirus from Leptochloa chinensis.

Arch Virol

January 2025

State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, China.

High-throughput sequencing was used to identify and characterize a novel marafivirus from the weed Leptochloa chinensis, which was tentatively named "Leptochloa chinensis marafivirus" (LcMV). The complete genome of the virus consists of 6,178 base pairs, and its nucleotide sequence is 73.82% identical to that of Sorghum almum marafivirus, which is a member of the genus Marafivirus within the family Tymoviridae.

View Article and Find Full Text PDF

The development of all-solid-state frustrated Lewis pairs (FLPs) metal-free hydrogenation catalysts with excellent activity and stability remains a significant challenge. In this work, B, N codoped FLPs catalysts (De-rGO-NB) were prepared by the strategy of fabricating carbon defects and heteroatom doping on the surface of reduced graphene oxide and applied in the selective hydrogenation of α,β-unsaturated aldehydes to unsaturated alcohols. It was found that electron-rich pyridine-N (Lewis base) and adjacent electron-deficient B-N (Lewis acid) sites could be constructed on the surface of reduced graphene oxide using dicyandiamide and metaboric acid as N and B sources, thus forming FLPs sites.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!