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Photoredox-Enabled Direct and Three-Component Difluoroalkylative Modification of -Aryl Glycinates.
Org Lett
January 2025
Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, Hubei 430074, China.
A Cu(I) photoredox-enabled reaction that selectively incorporates a difluoroalkyl group into -aryl glycine derivatives has been established. Using a bench-stable [PhPCFH]Br salt, the -CFH group could be installed either directly on the α-carbon of the glycine backbone or in a three-component fashion using an alkene as a bridge. A series of glycine derivatives have been evaluated, providing access to diverse unnatural amino esters and dipeptides with a -CHF unit.
View Article and Find Full Text PDFImpact of Centralisation of Radical Prostatectomy Driven by the Introduction of Robotic Systems on Positive Surgical Margin and Biochemical Recurrence in pT2 Prostate Cancer.
Cancer Med
January 2025
Department of Urology, Queen Elizabeth University Hospital, Glasgow, UK.
Background: To assess how centralisation of cancer services via robotic surgery influenced positive surgical margin (PSM) occurrence and its associated risk of biochemical recurrence (BCR) in cases of pT2 prostate cancer (PC).
Methods: Retrospective analysis of all radical prostatectomy (RP) cases performed in the West of Scotland during the period from January 2013 to June 2022. Primary outcomes were PSM and BCR.
HO Mediated Photoreduction of Nitrates to Ammonia by Iron Filings under Ambient Conditions.
J Phys Chem Lett
January 2025
Department of Chemistry, Malaviya National Institute of Technology, Jaipur, Jaipur 302017, India.
Herein, a simple ambient conditioned sunlight promoted photochemical reduction reaction is demonstrated for the of nitrate (NO) conversion to ammonia (NH) with the maximum conversion yield of ∼16 mM using iron filings (f-Fe) in the presence of HO. Based on a radical scavenging study of reactive species and the characterization of catalyst f-Fe before and after the reaction, a plausible mechanism has been proposed for the ambient conditioned synthesis of NH. The results associated with the NH synthesis have been verified using the N isotopic labeled nitrate (NO), which supports the simpler viability of the reported procedure.
View Article and Find Full Text PDFMnSOD non-acetylation mimic knock-in mice exhibit dilated cardiomyopathy.
Free Radic Biol Med
January 2025
Department of Radiation Oncology, Mays Cancer Center at UT Health San Antonio MD Anderson, Joe R. and Teresa Lozano Long School of Medicine, TX, USA. Electronic address:
Manganese superoxide dismutase (MnSOD/SOD2) is an essential mitochondrial enzyme that detoxifies superoxide radicals generated during oxidative respiration. MnSOD/SOD2 lysine 68 acetylation (K68-Ac) is an important post-translational modification (PTM) that regulates enzymatic activity, responding to nutrient status or oxidative stress, and elevated levels have been associated with human illness. To determine the in vivo role of MnSOD-K68 in the heart, we used a whole-body non-acetylation mimic mutant (MnSOD) knock-in mouse.
View Article and Find Full Text PDFRisk scoring system for evaluating pathological upstaging after radical nephroureterectomy for upper tract urothelial carcinoma: A multicenter study in Japan.
Int J Urol
January 2025
Division of Urology, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.
Objectives: Accurate preoperative staging of upper tract urothelial carcinoma is often difficult. Therefore, we aimed to investigate the preoperative factors associated with pathological upstaging in patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy and to develop a risk-scoring system to assess pathological upstaging.
Methods: This retrospective study enrolled 386 patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy at Tottori University Hospital and affiliated hospitals between January 2015 and December 2021.
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