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Cabozantinib Cutaneous Toxicity-Comprehensive Review.
Life (Basel)
January 2025
Department of Oncologic Dermatology, "Elias" Emergency University Hospital, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
In the context of modern cancer therapy, the management of adverse effects of systemic therapies can lead to the avoidance of underdosing and withdrawal and increases in the quality of the therapeutic act and the quality of life. This review offers an overview of the skin-related toxicities associated with Cabozantinib, a multikinase inhibitor (MKI) that is approved for treating advanced kidney cancer, hepatocellular carcinoma, and medullary thyroid cancer. It covers the most common dermatological side effects, such as palmar-plantar erythrodysesthesia, stomatitis, hair alterations, xerosis, scrotal erythema, and subungual splinter hemorrhages.
View Article and Find Full Text PDFUrethral Complications Due to Erythema Multiforme Major: A Case Report.
Cureus
December 2024
Department of Anatomy, A.T. Still University of Health Sciences - Kirksville College of Osteopathic Medicine, Kirksville, USA.
Erythema multiforme major (EMM) is an acute, immune-mediated mucocutaneous disease that rarely affects the genital mucosal surfaces. This study describes a 39-year-old male with this rare disease and unusual presentation. The patient presented to an emergency department with oral lesions, drainage from both eyes, injected sclera, and characteristic targetoid lesions on the face, upper extremities, torso, and plantar surfaces of the feet.
View Article and Find Full Text PDFClinical Characteristics and Management of Oral Candidiasis Associated with Calcinosis, Raynaud's Phenomenon, Esophageal Dysmotility, Sclerodactyly, and Telangiectasia Syndrome.
Cureus
December 2024
Department of Oral Medicine, Nihon University School of Dentistry, Tokyo, JPN.
Calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome, a systemic sclerosis subtype, features skin thickening, vascular issues, and organ involvement, causing complications in the gastrointestinal and musculoskeletal systems. Herein, we present a rare case of oral candidiasis, with CREST syndrome. The patient presented with xerostomia, tongue erythema, and burning pain.
View Article and Find Full Text PDFPredictive dermoscopic features of cryotherapy treatment response in cutaneous warts.
Sci Rep
November 2024
Department of Dermatology, Pusan National University Yangsan Hospital, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do, 50612, Republic of Korea.
The utility of dermoscopy for the diagnosis of cutaneous warts is well known. However, its role in predicting the outcome of cryotherapy for cutaneous warts remains unexplored. To identify dermoscopic features predicting treatment responses in cryotherapy for cutaneous warts.
View Article and Find Full Text PDFApplication of photodynamic therapy with 5-aminolevulinic acid and fractional CO laser for the management of recalcitrant plantar warts.
Photodiagnosis Photodyn Ther
November 2024
Department of Dermatology, Guangzhou Dermatology Hospital (Guangzhou Institute of Dermatology), Guangzhou, Guangdong 510095, China. Electronic address:
Article Synopsis
- Plantar warts, benign growths on the feet caused by HPV, are tough to eliminate completely, often leading to reappearance; this study looks at a dual treatment approach.
- Data from 10 patients with stubborn warts were analyzed after undergoing a combination of CO laser treatment and 5-ALA photodynamic therapy, yielding a 70% overall lesion clearance rate.
- This combined therapy proved to be effective and safe, suggesting it could be a good alternative for treating difficult plantar wart cases with minimal side effects.
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