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Tofacitinib treatment for plaque psoriasis and psoriatic arthritis: A meta-analysis of randomised controlled trials.
Indian J Dermatol Venereol Leprol
September 2024
Department of Traditional Chinese Medicine, The Second Clinical Medical College, Guangdong Medical University, Dongguan, Guangdong, China.
Article Synopsis
- Tofacitinib is an oral JAK inhibitor used to treat psoriatic disease, but there's no clear agreement on the best dosage or treatment duration.
- A meta-analysis of 7 randomized controlled trials involving 2,672 patients found that 5 mg of tofacitinib taken twice daily for 12 weeks significantly improved psoriasis symptoms compared to a placebo.
- The study also indicated that while extending treatment to 16 weeks did improve some aspects, it led to a higher risk of upper respiratory infections, suggesting that 12 weeks may be the optimal treatment duration.
Barriers to, Facilitators of, and Interventions to Support Treat-to-Target Implementation in Rheumatoid Arthritis: A Systematic Review.
Arthritis Care Res (Hoboken)
December 2024
University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom.
Objective: Treat-to-target is recommended in the management of rheumatoid arthritis (RA) but its implementation is suboptimal. We aimed to identify interventional strategies targeted at improving treat-to-target implementation in RA by systematically reviewing published evidence on barriers to, facilitators of, and interventions to support treat-to-target implementation.
Methods: Systematic and scoping literature searches in PubMed/MEDLINE, BIOSIS Previews, Derwent Drug File, Embase, EMCare, International Pharmaceutical Abstracts, and SciSearch were conducted to identify barriers/facilitators and interventions relating to treat-to-target implementation in RA.
Roles and challenges encountered by midwives in the management of postpartum haemorrhage following normal vaginal delivery: A scoping review.
Nurs Open
June 2024
Nursing Department, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Aims: To establish a comprehensive understanding of the roles of midwives and the challenges they encounter in the prevention, diagnosis and management of postpartum haemorrhage (PPH) following normal vaginal delivery.
Design: We conducted a scoping review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Scoping Reviews (PRISMA-ScR) recommendations.
Methods: We considered studies related to the roles of midwives and the challenges they encounter in the prevention, diagnosis and management of PPH during vaginal delivery.
Venous thromboembolism risk assessment scale for prediction of venous thromboembolism in inpatients with cancer: A meta-analysis.
Thromb Res
August 2024
Department of Nursing, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education/West China College of Nursing, Sichuan University, Chengdu, Sichuan Province 610041, PR China. Electronic address:
Aims: This meta-analysis was conducted to evaluate the validity of the Caprini venous thromboembolism (VTE) risk assessment scale in predicting the risk of VTE in inpatients with cancer.
Methods: Studies relating to the Caprini VTE risk assessment scale were systematically retrieved from the MEDLINE, EMBASE, Web of Science, Cochrane Library, BIOSIS Previews, EBSCOhost, and China National Knowledge Infrastructure (CNKI) databases up to May 1, 2022. Two reviewers independently conducted data extraction and quality evaluation.
Association of outdoor air and noise pollution with unprovoked seizures and new onset epilepsy: A systematic review and meta-analysis.
Epilepsia
July 2024
Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Article Synopsis
- Some research shows that being around certain air and noise pollution might make people have seizures or get epilepsy.
- This study looked at many different pieces of information to see if there is a link between pollution and these health issues.
- The results suggested that certain pollutants like ozone and nitrogen dioxide could slightly increase the chances of having seizures, but more studies are needed to confirm this.
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