Brief hypnosis substitutes for alprazolam use in college students: transient experiences and quantitative EEG responses.

We sought to determine: 1) whether a simple hypnotic induction with an alprazolam experience derived suggestion could recreate the subjective effects of alprazolam (Xanax), 2) whether the effects of alprazolam are greater than the effects of hypnosis plus this suggestion, and 3) whether the effects of hypnosis plus this suggestion were greater than the relaxation effects produced by hypnosis alone. High and low hypnotizable student volunteer subjects (Ss) ingested 1 mg of alprazolam. A hypnotic suggestion was developed on the basis of their reported reactions to alprazolam. Four days later the same Ss were exposed to hypnosis only and hypnosis plus the alprazolam experience based suggestion conditions in counterbalanced order. Ss exposed to the hypnosis plus suggestion condition demonstrated greater levels of relaxation as measured by the tension-anxiety scale of the Profile of Mood States (POMS) (Eichman & Umstead, 1971) than in the alprazolam condition or the hypnosis only condition. High hypnotizables showed significantly greater levels of relaxation than the low hypnotizables in each of the three conditions (hypnosis plus suggestion, hypnosis only, alprazolam only). EEG data showed frontal and occipital sites were specifically involved in both the alprazolam and the hypnotic suggestion conditions. The findings indicate a basis for the use of hypnosis as a substitute for sedative drug use. Limitations and implications for clinicians are discussed.