Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0079-6123(08)63552-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Glucose and NAADP trigger elementary intracellular β-cell Ca signals.
Sci Rep
May 2021
Department of Pharmacology, Mansfield Road, Oxford, OX1 3QT, UK.
Pancreatic β-cells release insulin upon a rise in blood glucose. The precise mechanisms of stimulus-secretion coupling, and its failure in Diabetes Mellitus Type 2, remain to be elucidated. The consensus model, as well as a class of currently prescribed anti-diabetic drugs, are based around the observation that glucose-evoked ATP production in β-cells leads to closure of cell membrane ATP-gated potassium (K) channels, plasma membrane depolarisation, Ca influx, and finally the exocytosis of insulin granules.
View Article and Find Full Text PDFBacFlash signals acid-resistance gene expression in bacteria.
Cell Res
June 2021
State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, 100871, China.
Intracellular pH (pH) homeostasis is crucial for cellular functions and signal transduction across all kingdoms of life. In particular, bacterial pH homeostasis is important for physiology, ecology, and pathogenesis. Here we report an exquisite bacterial acid-resistance (AR) mechanism in which proton leak elicits a pre-emptive AR response.
View Article and Find Full Text PDFRegulating quantal size of neurotransmitter release through a GPCR voltage sensor.
Proc Natl Acad Sci U S A
October 2020
State Key Laboratory of Membrane Biology and Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine and Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, 100871 Beijing, China
Current models emphasize that membrane voltage (Vm) depolarization-induced Ca influx triggers the fusion of vesicles to the plasma membrane. In sympathetic adrenal chromaffin cells, activation of a variety of G protein coupled receptors (GPCRs) can inhibit quantal size (QS) through the direct interaction of G protein Giβγ subunits with exocytosis fusion proteins. Here we report that, independently from Ca, Vm (action potential) per se regulates the amount of catecholamine released from each vesicle, the QS.
View Article and Find Full Text PDFModulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission.
Int J Mol Sci
September 2020
Department of Medical and Biological Physics with Computer Science and Medical Equipment, Kazan State Medical University, 49 Butlerov Street, 420012 Kazan, Russia.
A review of the data on the modulatory action of adenosine 5'-triphosphate (ATP), the main co-transmitter with acetylcholine, and adenosine, the final ATP metabolite in the synaptic cleft, on neuromuscular transmission is presented. The effects of these endogenous modulators on pre- and post-synaptic processes are discussed. The contribution of purines to the processes of quantal and non-quantal secretion of acetylcholine into the synaptic cleft, as well as the influence of the postsynaptic effects of ATP and adenosine on the functioning of cholinergic receptors, are evaluated.
View Article and Find Full Text PDFDelayed increase of acetylcholine quantal size induced by the activity-dependent release of endogenous CGRP but not ATP in neuromuscular junctions.
Synapse
December 2020
Department of Human and Animal Physiology, Biological Faculty, Lomonosov Moscow State University, Moscow, Russia.
In mouse motor synapses tetanic neuromuscular activity (30 Hz, 2 min) led to a delayed posttetanic potentiation of amplitude and duration of spontaneous miniature endplate potentials (MEPPs). Microelectrode recordings of MEPPs before and after nerve stimulation showed an increase in MEPP amplitude and time course by 30% and 15%, respectively, without changes in their frequency. Peak effect was detected 20 min after tetanic activity and progressively faded throughout the next 40 min of recording.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!