Dehydroepiandrosterone and exercise in golden hamsters.

Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are adrenal androgens that have been associated with a sense of well-being in humans. We describe two experiments done to test the hypothesis that an increase in DHEA or DHEAS secretion is associated with the inclination to exercise using a hamster model. In the first experiment, morning blood samples were obtained from adult male golden hamsters at various intervals after being placed in cages with (EX group) or without (SED group) access to running wheels. The EX group had lower DHEA (6, 12, and 14 weeks; p < 0.05) and DHEAS (13 and 16 weeks; p < 0.01) levels than the SED hamsters. In the second experiment, the number of wheel revolutions was monitored in castrated adult male hamsters implanted with Silastic capsules containing no hormone (blank control group), testosterone, or DHEA. The number of wheel revolutions in the group receiving DHEA was not significantly different than the blank control group, whereas testosterone increased wheel running at 4, 5, and 7 weeks (p < 0.05). These results indicate that DHEA and DHEAS levels decrease with exercise in male golden hamsters and that exogenous DHEA does not enhance the tendency to run on wheels.