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Comparison of hydroxocobalamin with other resuscitative fluids in volume-controlled and uncontrolled hemorrhage models in swine ( Sus-scrofa ).
J Trauma Acute Care Surg
August 2023
From the United States Air Force (R.M.P., D.R., J.M.), Clinical Resuscitation, Emergency Science, Triage and Toxicology (CRESTT); United States Air Force (M.C., A.A.M.), 59th Medical Wing, En route Care Research Center, Lackland AFB; Department of Emergency Medicine (J.M.), Brooke Army Military Medical Center; United States Army Institute of Surgical Research (USAISR) (J.M.), Ft Sam Houston, Texas; and F. Edward Hébert School of Medicine (J.M.), Uniformed Services University, Bethesda, Maryland.
Background: Traumatic hemorrhage is the leading cause of preventable death in military environments. Treatment with resuscitative fluids and blood components is based on availability, thus, frequently unavailable in the prehospital setting, due to lack of resources and costs. Hydroxocobalamin (HOC), increases blood pressure via nitric oxide scavenging.
View Article and Find Full Text PDFRole of Hemodialysis in the Management of Cyanide Intoxication From Apricot Kernels in a 3-Year-Old Child.
Pediatr Emerg Care
October 2020
Paediatric Cardiology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Cyanide (CN) is one among the most potent and rapidly acting lethal poisons, and it may cause death unless immediately diagnosed and treated. We report an unusual case of pediatric CN poisoning after ingestion of apricot kernels containing amygdalin, who survived with antidotal therapy and hemodialysis. A 3-year-old girl presented with respiratory distress and coma following tonic-clonic convulsions after ingestion of 3 apricot kernels.
View Article and Find Full Text PDFIntraosseous administration of antidotes - a systematic review.
Clin Toxicol (Phila)
December 2017
g Department of Medicine and Emergency Medicine , McGill University Health Centre, Montréal , Québec , Canada.
Context: Intraosseous (IO) access is an established route of administration in resuscitation situations. Patients with serious poisoning presenting to the emergency department may require urgent antidote therapy. However, intravenous (IV) access is not always readily available.
View Article and Find Full Text PDFSevere, acute cyanide poisoning is uncommon and can be very difficult to diagnose if a history of exposure is unavailable. Victims of smoke inhalation may have significant cyanide poisoning as well as carbon monoxide toxicity. The Lilly Cyanide Antidote Kit currently available in America unfortunately has its own inherent toxicity.
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