AI Article Synopsis
- The study explores how the secondary structures of oligonucleotides affect their interaction with DNA and RNA and their resistance to breakdown by nucleases.
- Oligonucleotides with structures like hairpins, loops, and snails are significantly more stable against nuclease degradation compared to linear oligonucleotides.
- These structured oligonucleotides are also capable of hybridizing effectively with their target DNA and RNA molecules.
Article Abstract
The influence of the secondary structure of oligonucleotides having a natural phosphodiester backbone on their ability to interact with DNA and RNA targets and on their resistance to the nucleolytic digestion is investigated. Oligonucleotides having hairpin, looped and snail-like structure are found to be much more stable to nuclease degradation in different biological media and inside cells than the linear ones. The structured oligonucleotides can also hybridise with their DNA and RNA targets.
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| http://dx.doi.org/10.1080/07328319908044865 | DOI Listing |
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