AI Article Synopsis
- The second day of pancreatitis in rats showed higher activities of cytochrome P450 2B1 and 2C6 when phenobarbital was injected compared to control rats.
- On the fourth day, the cytochrome P450 activities remained elevated, but by the tenth day, they were lower than in control animals after stopping the phenobarbital treatment.
- This indicates that rats with acute pancreatitis experience increased liver monooxygenase activity, and the return to normal levels occurs more rapidly than in non-affected rats.
Article Abstract
While injecting phenobarbital (PB) into the rats, on the second day of an experimental pancreatitis, cytochrome P450 2B1 and 2C6 activities were found, on the forth day of disease, as being considerably higher in comparison with data obtained in sham-operated control animals. On the tenth day of the acute pancreatitis (in three days upon having the induction canceled), activity of the cytochrome P450 isozymes was lower than that of control animals. Thus, the rats with acute pancreatitis, are characterized by an increased indycibility of liver monooxygenases. In addition, a release from induction (decrease of these activities upon having the induction canceled) proceeds faster than that in control animals.
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