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Thimet oligopeptidase (THOP 1) distribution in cane toad (Bufo Marinus, Linnaeus, 1758) brain.
J Chem Neuroanat
November 2023
Laboratory of Tissue and Development Biology, Veterinary Medicine College, Department of Animal Science, Center for Biological and Health Sciences, Universidade Federal Rural do Semiárido - UFERSA, Brazil.
Thimet oligopeptides (THOP 1) is a metal-dependent peptidase involved in the metabolism of neuropeptides and the presentation of peptides via MHC-1. It has been shown to play a role in the regulation of protein-protein interactions and the metabolism of intracellular peptides. THOP 1 is associated with important biological processes such as metabolism and neurodegenerative diseases, among others.
View Article and Find Full Text PDFPhAc-ALGP-Dox, a Novel Anticancer Prodrug with Targeted Activation and Improved Therapeutic Index.
Mol Cancer Ther
April 2022
CoBioRes NV, Campus Gasthuisberg University of Leuven, Leuven, Belgium.
Clinical use of doxorubicin (Dox) is limited by cumulative myelo- and cardiotoxicity. This research focuses on the detailed characterization of PhAc-ALGP-Dox, a targeted tetrapeptide prodrug with a unique dual-step activation mechanism, designed to circumvent Dox-related toxicities and is ready for upcoming clinical investigation. Coupling Dox to a phosphonoacetyl (PhAc)-capped tetrapeptide forms the cell-impermeable, inactive compound, PhAc-ALGP-Dox.
View Article and Find Full Text PDFThimet Oligopeptidase Biochemical and Biological Significances: Past, Present, and Future Directions.
Biomolecules
August 2020
Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, 7610001, Israel.
Thimet oligopeptidase (EC 3.4.24.
View Article and Find Full Text PDFCPP-Ala-Ala-Tyr-PABA inhibitor analogs with improved selectivity for neurolysin or thimet oligopeptidase.
Biochem Biophys Res Commun
February 2020
Departamento de Biofísica, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil. Electronic address:
Thimet oligopeptidase (TOP, EC 3.4.24.
View Article and Find Full Text PDFEP24.15 as a Potential Regulator of Kisspeptin Within the Neuroendocrine Hypothalamus.
Endocrinology
February 2016
Departments of Physiology and Biophysics (N.C.W., R.J.L., J.H.U.) and Biochemistry and Molecular Biology (N.C.W., K.D.P., M.W., M.J.G.), and Midwest Proteome Center (K.D.P., M.J.G.). Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064.
The neuropeptide kisspeptin (Kiss1) is integral to the advent of puberty and the generation of cyclical LH surges. Although many complex actions of Kiss1 are known, the mechanisms governing the processing/regulation of this peptide have not been unveiled. The metallo enzyme, endopeptidase 24.
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