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Morphological Signatures of Neurogenesis and Neuronal Migration in Hypothalamic Vasopressinergic Magnocellular Nuclei of the Adult Rat.
Int J Mol Sci
June 2024
Department of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 69120 Mannheim, Germany.
The arginine vasopressin (AVP)-magnocellular neurosecretory system (AVPMNS) in the hypothalamus plays a critical role in homeostatic regulation as well as in allostatic motivational behaviors. However, it remains unclear whether adult neurogenesis exists in the AVPMNS. By using immunoreaction against AVP, neurophysin II, glial fibrillar acidic protein (GFAP), cell division marker (Ki67), migrating neuroblast markers (doublecortin, DCX), microglial marker (Ionized calcium binding adaptor molecule 1, Iba1), and 5'-bromo-2'-deoxyuridine (BrdU), we report morphological evidence that low-rate neurogenesis and migration occur in adult AVPMNS in the rat hypothalamus.
View Article and Find Full Text PDFExploring the diversity of AVPR2 in Primates and its evolutionary implications.
Genet Mol Biol
November 2023
Universidade Federal do Rio Grande do Sul, Departamento de Genética, Laboratório de Evolução Humana e Molecular, Porto Alegre, RS, Brazil.
Article Synopsis
- This study looks at special protein variants in primates related to the AVPR2 receptor, which helps manage water in the body.
- The researchers found that some parts of this protein show changes that might help explain a rare kidney problem in humans that causes too much water loss.
- They also discovered that how these proteins evolved is linked to other important proteins, but the changes didn’t seem to depend on the different climates where these primates live.
Comparative reactivity of medicinal gold(I) compounds with the cyclic peptide vasopressin and its diselenide analogue.
Dalton Trans
December 2021
Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM, Pau, France.
The reactions of the medicinal gold(I) compound auranofin and its close analogues with vasopressin and the diselenide analogue were comparatively investigated by LC-electrospray MS/MS. Evidence is gained of the possible cleavage of the S-S and Se-Se bridges induced by Au(I). Notably, we found that, in the absence of reducing agents, the sulfur and selenium atoms are metallated only at high temperature (70 °C) with the preferential binding of gold to selenium.
View Article and Find Full Text PDFCopeptin as a novel biomarker of cardiometabolic syndrome.
Endokrynol Pol
March 2022
Department of Endocrinology, Diabetology, and Metabolic Disorders, Medical University of Lublin, Lublin, Poland.
Arginine vasopressin (AVP), which is also called antidiuretic hormone (ADH), is a neurohormone synthetized from a pre-pro-hormone precursor in the supraoptic and paraventricular nuclei of the hypothalamus in response to increased plasma osmolality and decreased blood volume. AVP exerts several effects by binding to three different receptors: V1aR, V1bR, and V2R. In recent years, it has been suggested that increased plasma concentration of AVP may play a causal role in the development of type 2 diabetes, the metabolic syndrome, renal dysfunction and cardiovascular disease by influencing glucose homeostasis and lipid metabolism through several possible mechanisms involving V1aR and V1bR.
View Article and Find Full Text PDFIntroduction: Hypothalamic hamartoma (HH) is a rare developmental disorder presenting with gelastic seizures or precocious puberty attributed to gonadotrophin-releasing hormone expression by the hamartoma. The histogenesis of HH is uncertain, and diagnosis of HH is difficult in small biopsies due to its close resemblance to normal hypothalamic nuclei. TTF-1 and arginine vasopressin (AVP) are associated with gonadotropin-releasing hormone release.
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