Four week old male Wistar rats were used to study the effects of scopoletin and cyanide on the histopathology of rat brain. The rats were divided into a control and three experimental groups (2-4) and fed rations containing 0.07 microg scopoletin/100 g, 0.07 microg scopoletin + 1.8 mg cyanide/100 g and 1.8 mg cyanide/100 g, respectively. These levels of scopoletin and cyanide corresponded to levels found in a processed cassava diet. The first group was fed the same ration as the others but without scopoletin and cyanide. The rats were fed these rations for twelve months. Rats from each group were sacrificed at the third, sixth, ninth and twelfth months; the relative brain weight of the rats (% of body weight) and histology of their brains were studied. The lipid peroxide levels of the rat brains were also studied at the twelfth month. The results showed that the relative brain weights of the rats fed scopoletin + cyanide were significantly (p<0.05) less than that of the control from the third month. There were no significant changes in the lipid peroxide levels of the rat brains in the various groups. Histological examination of the brains of the rats suggested that scopoletin is involved in the pathogenesis of the neuropathy seen in cassava consuming populations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1023/a:1008096801895 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Toxic Potential of Crude Extract From Cassava Cortex Containing Scopoletin and Cyanide on Wistar Rats and Broilers.
Dose Response
September 2023
Laboratory of Food Technology, Institute of Agricultural Research for Development (IRAD), Yaoundé, Cameroon.
The present work aimed to evaluate acute and sub-acute toxicity of cortex cassava crude extract containing scopoletin and cyanide. The limit test method of OECD at 2000 mg/kg was used to determine the LD of the crude extract in female Wistar rats, and the sub-acute toxicity was conducted in broilers by incorporating their feed with the cortex powder at 2 mg, 4 mg and 8 mg of powder per 100 g of standard food, corresponding to MIC, 2MIC and 4MIC: those concentrations, respectively, corresponded to .07 μg, .
View Article and Find Full Text PDFRole of Synthetic Plant Extracts on the Production of Silver-Derived Nanoparticles.
Plants (Basel)
August 2021
Research Group FiVe-A, Plant Physiology Unit, Faculty of Biology, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain.
The main antioxidants present in plant extracts-quercetin, β-carotene, gallic acid, ascorbic acid, hydroxybenzoic acid, caffeic acid, catechin and scopoletin-are able to synthesize silver nanoparticles when reacting with a Ag NO solution. The UV-visible absorption spectrum recorded with most of the antioxidants shows the characteristic surface plasmon resonance band of silver nanoparticles. Nanoparticles synthesised with ascorbic, hydroxybenzoic, caffeic, and gallic acids and scopoletin are spherical.
View Article and Find Full Text PDFHepatic Necrosis and Degenerative Myopathy Associated with Cassava Feeding in Pigs.
J Vet Med
October 2015
Department of Veterinary Pathology, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike PMB 7267, Abia State, Nigeria.
Forty-three deaths were recorded among pigs fed boiled cassava meal at a private piggery over a period of two years. There were signs of sudden death in some cases with blood exuding from the external nares, vomiting, muscular weakness and pain or reluctance to move, emaciation, and stunted growth. The necropsy lesions included skeletal and cardiac muscle degeneration and necrosis, icterus, hepatic necrosis, and oedema of the dependent parts.
View Article and Find Full Text PDFNitric oxide-mediated augmentation of neutrophil reactive oxygen and nitrogen species formation: Critical use of probes.
Cytometry A
November 2010
Pharmacology Division, Central Drug Research Institute (Council of Scientific and Industrial Research), Lucknow, India.
Previous reports from this laboratory and others demonstrated NO-mediated biphasic modulation of NADPH oxidase and attenuation of neutrophil reactive oxygen species generation, whereas recently we reported augmentation in DCF fluorescence following NO treatment. These discrepancies seem to be due to utilization of different probes/methods to assess effect of NO on reactive oxygen and nitrogen species (ROS/RNS, reactive species) generation. This study aims to look into this and evaluate NO-mediated enzymatic reactive species formation by using multiple probes, human neutrophils/HL60 cells and various interventions.
View Article and Find Full Text PDFComparative effects of scopoletin and cyanide on rat brain, 1: histopathology.
Plant Foods Hum Nutr
November 1999
Department of Biochemistry, College of Medical Sciences, University of Maiduguri, Nigeria.
Four week old male Wistar rats were used to study the effects of scopoletin and cyanide on the histopathology of rat brain. The rats were divided into a control and three experimental groups (2-4) and fed rations containing 0.07 microg scopoletin/100 g, 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!