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Nono induces Gadd45b to mediate DNA repair.
Life Sci Alliance
August 2024
Mildred Scheel Early Career Center for Cancer Research (Mildred-Scheel-Nachwuchszentrum, MSNZ) Würzburg, University Hospital Würzburg, Würzburg, Germany
RNA-binding proteins are frequently deregulated in cancer and emerge as effectors of the DNA damage response (DDR). The non-POU domain-containing octamer-binding protein NONO/p54 is a multifunctional RNA-binding protein that not only modulates the production and processing of mRNA, but also promotes the repair of DNA double-strand breaks (DSBs). Here, we investigate the impact of deletion in the murine KP ( , ) cell-based lung cancer model.
View Article and Find Full Text PDFUBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma.
Cell Mol Gastroenterol Hepatol
April 2022
Department of Radiation Oncology, Ann Arbor, Michigan. Electronic address:
Background & Aims: TP53 mutations underlie Barrett's esophagus (BE) progression to dysplasia and cancer. During BE progression, the ubiquitin ligase (E3) RNF128/GRAIL switches expression from isoform 2 (Iso2) to Iso1, stabilizing mutant p53. However, the ubiquitin-conjugating enzyme (E2) that partners with Iso1 to stabilize mutant p53 is unknown.
View Article and Find Full Text PDFCurcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line.
Oncotarget
May 2017
Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
Malignant mesothelioma (MM) is a primary tumor arising from the serous membranes. The resistance of MM patients to conventional therapies, and the poor patients' survival, encouraged the identification of molecular targets for MM treatment. Curcumin (CUR) is a "multifunctional drug".
View Article and Find Full Text PDF25th Annual Computational Neuroscience Meeting: CNS-2016.
BMC Neurosci
August 2016
Institut de Neuroscienes de la Timone (INT), CNRS & Aix-Marseille University, 27 Boulevard Jean Moulin, 13005 Marseille, France
Article Synopsis
- The text includes a collection of research topics related to neural circuits, mental disorders, and computational models in neuroscience.
- It features various studies examining the functional advantages of neural heterogeneity, propagation waves in the visual cortex, and dendritic mechanisms crucial for precise neuronal functioning.
- The research covers a range of applications, from understanding complex brain rhythms to modeling auditory processing and investigating the effects of neural regulation on behavior.
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015.
BMC Genomics
July 2016
Centre of Excellence in Genomic and Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
O1 Regulation of genes by telomere length over long distances Jerry W. Shay O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa O3 Integration of metagenomics and metabolomics in gut microbiome research Maryam Goudarzi, Albert J.
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