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Eur J Cancer
March 2025
Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Larotrectinib is the first-in-class, highly selective TRK inhibitor with demonstrated efficacy in various TRK fusion solid tumours. We report the efficacy and safety of larotrectinib in patients with TRK fusion gastrointestinal (GI) cancer.
Methods: Patients with TRK fusion GI cancer from NAVIGATE (NCT02576431) were included.
J Zoo Wildl Med
March 2025
Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University, Botucatu, 18618-681, São Paulo, Brazil.
This study aimed to perform upper digestive endoscopy in clinically healthy coatis (), based on descriptions in domestic dogs and cats. In addition, research was carried out for r in stomach samples. Five adult male coatis, weighing between 2.
View Article and Find Full Text PDFAnn Afr Med
March 2025
Department of Community Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.
Background/aim: Tobacco addiction is prevalent in South and Southeast Asia. This study aimed to assess upper gastrointestinal (GI) tract changes in smokeless tobacco (SLT) users through upper GI endoscopy (UGIE).
Materials And Methods: A cross-sectional observational study, including 108 SLT users and 90 controls who did not use tobacco, was conducted at an Indian tertiary care hospital from March 2022 to February 2023.
J Appl Biomed
December 2024
Institute for Clinical and Experimental Medicine, Department of Hepatogastroenterology, Prague, Czech Republic.
Background/aims: The functional lumen imaging probe (FLIP) relies on the principle of impedance planimetry that enables direct measurement of intraluminal pressure, cross-sectional areas, and wall biomechanical properties. The aim of our pilot project was to introduce this method to assess function of the lower oesophageal sphincter and pyloric muscle in experimental pigs.
Methods: All measurements were accomplished in one session in six adult female pigs (mean weight 34.
Pediatr Int
January 2025
Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
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