The purpose of this study was to evaluate the diagnostic sensitivity of phalangeal bone ultrasound velocity of the hand in the diagnosis of osteoporosis and to compare this technique to bone mineral density (BMD) measurement at the lumbar spine assessed by dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). We investigated US velocity at the distal metaphysis of the proximal phalanx and spinal BMD in 101 women. Fifty-nine were healthy (mean age 50 +/- 11.6 years) and 42 were osteoporotic (mean age 65 +/- 6.6 years) with documented vertebral fractures. In the healthy population the relation with age was, respectively, r = -0.73 (p < 0. 0001) for quantitative US (QUS), r = -0.74 (p < 0.0001) for QCT and r = -0.48 (p < 0.01) for DXA. Both US and DXA were correlated with QCT: r = 0.74 and r = 0.77 (p < 0.0001), respectively. Correlation of QUS and DXA was r = 0.56 (p < 0.0001). Phalangeal US velocity and spinal BMD (QCT and DXA) values discriminate healthy from osteoporotic women. Age-adjusted logistic regression analysis of the data showed standardized odds ratios (OR) for vertebral fracture to be similar for US and DXA (OR = 1.8 and 1.5, respectively) and stronger for QCT (OR = 2.9). Phalangeal US velocity reflects age-related bone loss and differentiates between healthy and osteoporotic subjects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s003300050899 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Novel TRPS1 frameshift variant in tricho-rhino-phalangeal syndrome type I accompanied by zinc deficiency.
Eur J Med Genet
December 2023
Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Tricho-rhino-phalangeal syndrome type I (TRPS1), caused by pathogenic variants in the transcriptional repressor GATA-binding 1 gene (TRPS1), is characterized by ectodermal and skeletal anomalies including short stature and sparse scalp hair during infancy. TRPS1 encodes a zinc finger protein transcription factor that contributes to bone homeostasis by regulating perichondral mineralization, chondrocyte proliferation, and apoptosis. Here, a male infant aged 14 months presented with sparse scalp hair, deformed nails, fused teeth, and postnatal growth retardation without neurodevelopmental disorder.
View Article and Find Full Text PDFThe Use of External Fixator and Iliac Crest Bone Graft in Traumatic Metacarpal Bone Defect.
J Orthop Case Rep
December 2022
Department of Orthopedics and Traumatology, Istanbul Medipol University, Istanbul, Turkey.
Article Synopsis
- Metacarpal bone fractures can cause significant shortening of the phalanges, affecting function and appearance, often due to various types of injuries or conditions.
- A case involving a 22-year-old male with a traumatic fracture in the second metacarpal was treated using an external fixator to lengthen the bone and reconstruct the defect with an iliac crest graft.
- Proper surgical techniques and early rehabilitation can lead to successful outcomes with minimal complications following metacarpal fractures.
Recombinant Human Growth Hormone Therapy for Childhood Trichorhinophalangeal Syndrome Type I: A Case Report.
Children (Basel)
September 2022
Department of Endocrinology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.
Trichorhinophalangeal syndrome type I (TRPS I; MIM 190350) is a rare autosomal dominant disorder of congenital malformations due to variants of the gene TRPS1. We reported on an 11-year-old Chinese boy with TRPS I. He had typical clinical findings, including sparse hair, a bulbous nose, a long philtrum, a thin upper lip, and skeletal abnormalities including cone-shaped epiphyses, shortening of the phalanges, and short stature.
View Article and Find Full Text PDFAn Examination of Trunk and Right-Hand Coordination in Piano Performance: A Case Comparison of Three Pianists.
Front Psychol
June 2022
Department of Kinesiology, University of Lethbridge, Lethbridge, AB, Canada.
Playing the piano at expert levels typically involves significant levels of trial-and-error learning since the majority of practice occurs in isolation. To better optimize musical outcomes, pianists might be well served by emulating some of the practices found in sports, where motor learning strategies are grounded in biomechanics and ergonomics in order to improve performance and reduce risk of performance-related injuries. The purpose of the current study is to examine trunk-hand coordination and preparatory movement strategization in piano performance, while considering the influence of anthropometry, skill level of the performer, and musical context.
View Article and Find Full Text PDFKinematic and dynamic aspects of chimpanzee knuckle walking: finger flexors likely do not buffer ground impact forces.
J Exp Biol
October 2021
Muscles & Movement Group, Department of Development and Regeneration, KU Leuven Campus Kulak, 8500 Kortrijk, Belgium.
Chimpanzees are knuckle walkers, with forelimbs contacting the ground by the dorsum of the finger's middle phalanges. As these muscular apes are given to high-velocity motions, the question arises of how the ground reaction forces are buffered so that no damage ensues in the load-bearing fingers. In the literature, it was hypothesized that the finger flexors help buffer impacts because in knuckle stance the metacarpophalangeal joints (MCPJs) are strongly hyperextended, which would elongate the finger flexors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!