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Pharmacologic Management of Heart Failure with Preserved Ejection Fraction (HFpEF) in Older Adults.
Drugs Aging
January 2025
Program for the Care and Study of the Aging Heart, Department of Medicine, Weill Cornell Medicine, 420 East 70th St, New York, NY, LH-36510063, USA.
There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with preserved ejection fraction (HFpEF). However, it is important to recognize that older adults with HFpEF also contend with an increased risk for adverse effects from medications due to age-related changes in pharmacokinetics and pharmacodynamics of medications, as well as the concurrence of geriatric conditions such as polypharmacy and frailty. With this review, we discuss the underlying evidence for the benefits of various treatments in HFpEF and incorporate key considerations for older adults, a subpopulation that may be at higher risk for adverse drug events.
View Article and Find Full Text PDFDevelopment of an interactive ultra-high resolution magnetic resonance neurography atlas of the brachial plexus and upper extremity peripheral nerves.
Clin Imaging
January 2025
Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, United States of America. Electronic address:
Purpose: To develop an educational, interactive, ultra-high resolution, in vivo magnetic resonance (MR) neurography atlas for direct visualization of the brachial plexus and upper extremity.
Methods: A total of 16 adult volunteers without known peripheral neuropathy underwent magnetic resonance (MR) neurography of the brachial plexus and upper extremity. To improve vascular suppression, subjects received an intravenous infusion of ferumoxytol.
[Advances in urinary and male genital system pathology in China over the past ten years: retrospect and prospect].
Zhonghua Bing Li Xue Za Zhi
January 2025
Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing210002, China.
Over the past decade, the field of urological and male reproductive system pathology has experienced rapid development. Numerous accomplishments were achieved in clinical diagnosis and molecular research in this area in China, gradually gaining international recognition. As the most influential academic journal in the field of pathology in China, the Chinese Journal of Pathology has witnessed the vigorous growth and innovation in this domain.
View Article and Find Full Text PDF[Inherit and develop, innovate and move forward: celebrating the 70th anniversary of Chinese Journal of Pathology].
Zhonghua Bing Li Xue Za Zhi
January 2025
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Pathology Quality Control Center, Beijing100730, China.
Frailty in older adults with systemic lupus erythematosus and emergency department utilization: an administrative claims data analysis of Medicare beneficiaries.
Clin Rheumatol
December 2024
Division of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA.
Introduction / Objectives: While presence of concomitant SLE and frailty has been associated with greater emergency department (ED) use than SLE alone in young/mid-aged adults, whether frailty increases ED use in older adults with SLE remains unknown. In a nationally representative United States administrative claims dataset, we investigated the association of frailty duration with use of ED services in the SLE population compared with individuals without systemic rheumatic disease (SRD).
Method: We identified Medicare beneficiaries ≥ 65 years with SLE and matched them (1:4) by age and gender with non-SRD comparators with osteoarthritis.
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