A random screening approach has identified 2-chloro-3-substituted-1,4-naphthoquinones as potent inactivators of HCMV protease. Enzyme inactivation is due to modification of Cys202. Two of the most potent compounds maintain activity against HCMV in a plaque reduction assay.
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| http://dx.doi.org/10.1016/s0960-894x(99)00489-8 | DOI Listing |
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