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Pathogenesis and management of -related Olmsted syndrome.
Front Genet
December 2024
Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China.
Olmsted syndrome is characterized by symmetrically distributed, destructive, inflammatory palmoplantar keratoderma with periorificial keratotic plaques, most commonly due to gain-of-function mutations in the transient receptor potential vanilloid 3 (TRPV3) gene, which involves multiple pathological functions of the skin, such as hyperkeratosis, dermatitis, hair loss, itching, and pain. Recent studies suggest that mutations of located in different structural domains lead to cases of varying severity, suggesting a potential genotype-phenotype correlation resulting from TRPV3 gene mutations. This paper reviews the genetics and pathogenesis of Olmsted syndrome, as well as the potential management and treatment.
View Article and Find Full Text PDFThe vulva is a periorificial skin area and as such represents a transitional zone with unique functional and physiological characteristics. Knowledge of its anatomy is limited among both the general population and healthcare professionals, and unrealistic expectations of normal proportions are common. Ignorance of anatomical variations can cause unnecessary anxiety.
View Article and Find Full Text PDFSuccessful Use of Photodynamic Therapy for Treatment of Palbociclib-Induced Periorificial Dermatitis.
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Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
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Treatment of Common Dermatologic Conditions.
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Department of Internal Medicine, Division of General Internal Medicine, University of Washington, Box 354760, 4245 Roosevelt Way Northeast, 3rd Floor, Seattle, WA 98105, USA.
Article Synopsis
- Dermatologic issues are a significant part of primary care, appearing in about one-third of visits.
- The review focuses on common skin conditions like alopecia, facial rashes, and various types of dermatitis, highlighting new and emerging treatment options.
- It aims to enhance primary care providers’ prescribing confidence and awareness of potential side effects associated with more aggressive dermatological treatments.
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