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A Case of Application of Computer-Aided Design and Manufacturing Technology and Extended Reality Surgical Assistance to Marginal Mandibulectomy.
J Clin Med
December 2024
Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
Mandibular gingival squamous cell carcinoma (SCC) is the second most common oral cancer after tongue cancer. As these carcinomas often invade the mandible early, accurately defining the resection extent is important. This report highlights the use of preoperative virtual surgery data, computer-aided design and manufacturing (CAD/CAM) technology, surgical guidance, and extended reality (XR) support in achieving highly accurate marginal mandibulectomy without recurrence or metastasis.
View Article and Find Full Text PDFGingival Metastasis After Surgery for Early-Stage Lung Adenocarcinoma.
Ann Thorac Surg Short Rep
December 2024
Department of Thoracic Surgery, Japanese Red Cross Osaka Hospital, Osaka, Japan.
A 69-year-old male patient underwent a left upper lung lobectomy and nodal dissection for left upper lung adenocarcinoma. His pathologic stage was pT2aN0M0, stage 1B. He received oral tegafur/uracil for adjuvant chemotherapy and visited our hospital every 2 months.
View Article and Find Full Text PDFTumor-Derived GDF15 Induces Tumor Associated Fibroblast Transformation From BMSCs and Fibroblasts in Oral Squamous Cell Carcinoma.
J Cell Physiol
January 2025
Department of Oral and Maxillofacial Surgery, Qilu Hospital of Shandong University, Jinan, China.
Cancer associated fibroblasts (CAFs) are the predominant stromal cell-type in the solid tumor microenvironment, originating from various cell types and playing a crucial role in promoting tumor progression and metastasis The generation of CAFs is influenced by complex factors secreted by tumor cells, with particular emphasis on transforming growth factor-β (TGF-β). However, it remains largely unknown whether growth/differentiation factor-15 (GDF15), as a member of the TGF-β superfamily, exerts similar effects to TGF-β in oral squamous cell carcinoma (OSCC). In this study, we investigated the impact of GDF15 derived from tumor cells on CAF transformation and elucidated the underlying mechanisms.
View Article and Find Full Text PDFRegulation of Tumor Growth and Invasion in Oral Squamous Cell Carcinoma by the Tumor Microenvironment Through the Enhancement of IGFBP-3 Expression.
Anticancer Res
December 2024
Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam, Republic of Korea
Background/aim: Accumulated evidence indicates that interactions among various stromal cells within the tumor microenvironment (TME) significantly influence cancer progression. Oral cancers not diagnosed at early stages are associated with low five-year survival rates, highlighting the need for substantial improvements in patient outcomes. Understanding the interactions between cancer cells and the tumor microenvironment is crucial for identifying methods and developing treatment strategies that more effectively inhibit tumor progression and metastasis.
View Article and Find Full Text PDFCisplatin intra-arterial chemotherapy for recurrent maxillary gingival cancer and metastatic lymph nodes without radiation or surgery: A case report.
Radiol Case Rep
January 2025
Department of Radiology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo-Ku, Sapporo City, Hokkaido 060-8556, Japan.
Most patients with head and neck cancers struggle with their treatment, particularly those with recurrent cancer. However, there is no consensus on effective treatments for recurrent head and neck cancer. Recurrent cases are often challenging to treat because performing both reirradiation and surgical intervention can occasionally be difficult.
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