Background: Relative hypotension has been reported in sickle cell patients. The aim of this study was to compare blood pressure in patients with SS disease and subjects with normal hemoglobin genotype AA and to assess whether the same clinical, biological and socio-demographic variables are associated to the mean arterial pressure in patients with sickle cell disease and normal subjects.
Method: Blood pressure was measured with a standardized automated oscillometric method in 88 SS patients et 88 AA control subjects seen in the University Hospital of Pointe-à-Pitre (Guadeloupe). A multiple linear regression analysis for mean arterial pressure was done including type of hemoglobin (forced variable), age, sex, body mass index, pulse rate, hemoglobin concentration and interaction terms between type of hemoglobin and other variables. A regression was also fitted separately for each population. A downward stepwise strategy was used to simplify the models.
Results: The two groups were similar for age, height and gender ratio and pulse rate. Mean arterial pressure was significantly lower in sickle cell patients (81.6 mmHg in SS patients vs 89.9 mmHg in AA subjects, p < 10(-4)). The final model included type of hemoglobin, age, sex, body mass index, pulse rate and an interaction between type of hemoglobin and age (global F = 22.04, adjusted R2 = 42%). The separate models indicated that sex was associated with mean arterial pressure only in patients with sickle cell disease and that age and hemoglobin concentration was associated with mean arterial pressure only in normal subjects.
Conclusion: Blood pressure determinants are not similar in the two populations. The effect of age, especially, is not the same in patients with sickle cell disease and in normal subjects. These results confirm that specific patho-physiological models should be defined in sickle cell disease.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
TARGETING LUNG HEME IRON BY AEROSOL HEMOPEXIN ADMINSTRATION IN SICKLE CELL DISEASE PULMONARY HYPERTENSION.
Free Radic Biol Med
January 2025
University of Colorado, Anschutz Medical Campus School of Medicine| Translational research laboratory of Red Blood Cell Diseases and Hypoxia related illnesses| Cardiovascular Pulmonary Research (CVP) group, Pediatrics. Electronic address:
Lung tissue from human patients and murine models of sickle cell disease pulmonary hypertension (SCD-PH) show perivascular regions with excessive iron accumulation. The iron accumulation arises from chronic hemolysis and extravasation of hemoglobin (Hb) into the lung adventitial spaces, where it is linked to nitric oxide depletion, oxidative stress, inflammation, and tissue hypoxia, which collectively drive SCD-PH. Here, we tested the hypothesis that intrapulmonary delivery of hemopexin (Hpx) to the deep lung is effective at scavenging heme-iron and attenuating the progression of SCD-PH.
View Article and Find Full Text PDFCardiovascular Anesthesia and Critical Care in the French West Indies: Historical Evolution and Current Prospects.
J Clin Med
January 2025
Department of Cardiovascular & Thoracic Anaesthesia and Critical Care, University Hospital of Martinique, F-97200 Fort de France, France.
Anesthesiology, the medical specialty that deals with the management of vital functions in patients undergoing surgery, has played an important role in the successful development of cardiac interventions worldwide. Tracing the historical roots of cardiac anesthesia and critical care from its inception in the late 1950s, a paradigm shift in perioperative care has been driven by a better understanding of the mechanisms of organ dysfunction in stressful conditions and technological advances regarding surgical approach, patient monitoring, and organ protection. Although progress in cardiac anesthesia and critical care lagged a little behind in Caribbean territories, successful achievements have been accomplished over the last forty years.
View Article and Find Full Text PDFHemoglobin Variants as Targets for Stabilizing Drugs.
Molecules
January 2025
Faculty of Science, Pavol Jozef Šafárik University in Košice, Park Angelinum 19, 040 01 Košice, Slovakia.
Hemoglobin is an oxygen-transport protein in red blood cells that interacts with multiple ligands, e.g., oxygen, carbon dioxide, carbon monoxide, and nitric oxide.
View Article and Find Full Text PDFComparison of Asymptomatic Brain Lesions Between Thalassemia Major and Sickle Cell Anemia Patients.
Medicina (Kaunas)
January 2025
Department of Thalassemia Unit, Hatay Education and Research Hospital, Hatay 31027, Turkey.
This study aimed to identify asymptomatic brain lesions in patients with β-thalassemia major (TM) and sickle cell anemia (SCA) and evaluate the correlation of these lesions with factors such as splenectomy, thrombocytosis, and blood transfusions. A total of 26 patients with thalassemia major and 23 patients with sickle cell anemia were included. Ischemic lesions were categorized as lacunar, small vessel, or multifocal.
View Article and Find Full Text PDFSickle Cell Disease in the Islands of Zanzibar: Patients' Characteristics, Management, and Clinical Outcomes.
Genes (Basel)
January 2025
Mnazi Mmoja Hospital (MMH), Kaunda Road, Vuga Street, Zanzibar 71102, Tanzania.
Background: This study aimed to describe Sickle Cell Disease (SCD) phenotypes, sociodemographic characteristics, healthcare, and clinical outcomes of patients with SCD attending Mnazi Mmoja Hospital (MMH) in Zanzibar.
Methods: Individuals who visited MMH between September 2021 and December 2022 and were known or suspected to have SCD were enrolled in the clinic. Sociodemographic characteristics and clinical features were documented, and laboratory tests were performed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!