[Ednit influence on oxidation resistance of LDL lipoproteins in hypertensive subjects].

Aim: Evaluation of resistance of low density lipoproteins (LDLP) of the serum to oxidation in patients with essential hypertension (EH) before and after course treatment with ednit.

Materials And Methods: 10 patients with mild or moderate EH aged 38-58 years were given ednit for 1 or 2 months. 10 healthy males aged 35-48 years served control.

Results: EH patients had high baseline levels of lipid peroxidation products in LDLP, while antioxidant resistance of LDPL was diminished by 67% (p < 0.05) compared to controls. Ednit treatment for 1 and 2 months enhanced this resistance in mild and moderate EH (p < 0.05).

Conclusion: Ednit raises resistance of LDLP to oxidation and as ACE inhibitor lowers arterial pressure. Therefore it can be used in EH.