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Cardiovascular Complications Following Acute Methadone Poisoning in Patients with and Without a History of Long-term Methadone Use.
J Res Pharm Pract
December 2024
Department of Clinical Toxicology, Isfahan University of Medical Sciences, Isfahan, Iran.
Objective: Given the prevalence of methadone poisoning, this study was conducted to compare the cardiovascular complications following acute methadone poisoning in patients with and without a history of long-term methadone use.
Methods: In this retrospective study, information related to patients with acute methadone poisoning hospitalized at Al-Zahra and Khorshid hospitals in Isfahan-Iran was collected from hospital archives and analyzed. Patients were divided into two groups with and without a history of long-term methadone use.
Evaluation of acute substance abuse patients admitted to the ICU by different scoring system.
Toxicol Res (Camb)
February 2025
Department of Forensic Medicine and Clinical Toxicology, Champollion street, Faculty of Medicine, University of Alexandria, Alexandria, 21517, Egypt.
Drug abuse poisoning is a significant public health problem in many countries all over the world. The recent study aimed to assess the applicability of NEWS II and APACHE II scores as predictors of the ICU admission of acute intoxication by substance abuse. The study enrolled 98 patients admitted to the Alexandria Poison Center of the Main University Hospital (APC-AMUH) with a history of acute intoxication with substance abuse.
View Article and Find Full Text PDFThe potential role of N-acetylcysteine as an adjuvant therapy in acute aluminum phosphide poisoning: a randomized clinical trial.
Toxicol Res (Camb)
February 2025
Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Menoufia University, Yassen Abd Al Ghafar Street, Shibin El-Kom 6132720, Egypt.
Objective: Aluminum phosphide (AP) intoxication is a life-threatening emergency with no available effective antidote. This study evaluated the efficacy and safety of N-acetylcysteine (NAC) infusion in cases of acute AP poisoning.
Methods: This randomized, single-blinded, parallel-group, controlled, clinical trial enrolled 96 patients with acute AP poisoning.
Acute zinc sulfate overdose: clinical presentation and management.
BMJ Case Rep
January 2025
Emergency Medicine Department, King Abdulaziz Medical City in Riyadh, Riyadh, Saudi Arabia.
A woman in her 40s with a history of depression, diabetes, zinc deficiency and gastric bypass surgery presented to the emergency department following the intentional ingestion of ninety 50 mg tablets of zinc sulfate. She exhibited gastrointestinal distress without systemic toxicity. Imaging revealed radiopaque tablets in the abdomen, and her management was primarily supportive, focusing on symptom control and hydration.
View Article and Find Full Text PDFMitochondrial targeted drug Dichloroacetate protects against sulfur mustard-induced neurotoxicity via the PDK/PDH axis and Akt/Nrf2 pathway.
Free Radic Biol Med
January 2025
Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.. Electronic address:
Sulfur mustard (SM) is a major toxic chemical threat to public health. Mitochondrial dysfunction is considered a critical contributing factor to mustard agent-induced damage. The brain is vulnerable to SM, which can lead to various types of acute and long-term psychiatric distress after exposure, but the neurotoxic mechanisms of SM, let alone drug candidates, are seldom studied.
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