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The Mickey Mouse's hand sign in brain MRI points out multinodular and vacuolating neuronal tumors in mesial temporal lobe structures.
J Neurooncol
March 2025
Epilepsy and EEG Unit, Department of Neurology, Pitié-Salpêtrière Hospital, Reference Center for Rare Epilepsies, ERN-EPICARE, AP-HP, 75013, Paris, France.
Purpose: Multinodular and vacuolating neuronal tumor (MVNT) is a rarely diagnosed neoplastic lesion often associated with adult-onset focal seizures. In some situations, atypical MRI features of MVNT may mimic other long-term epilepsy associated tumors (LEATs) or diffuse low-grade gliomas. In such a context, the identification of distinct clinical markers is recommended.
View Article and Find Full Text PDFRare glioblastoma subtype masquerading as a poorly differentiated carcinoma: illustrative case.
J Neurosurg Case Lessons
March 2025
Institute of Pathology, Pathology Center Zurich, Medica Laboratories Zurich, Switzerland.
Background: Glioblastoma (GBM) with a primitive neuronal component (PNC) is a recently characterized subtype with a characteristic (epi-)genetic profile and ambiguous microscopic features mimicking a metastasis, making intraoperative diagnosis challenging.
Observations: A 62-year-old female presented with word-finding difficulties. MRI showed 2 contrast-enhancing lesions in the temporal lobe.
Mixed Glioneural Tumors Mimicking Gliomas: Two Cases From a Tertiary Care Institute in South India and a Literature Review.
Cureus
January 2025
Neurological Surgery, Mahatma Brain and Spine Centre, Madurai, IND.
Glioneuronal tumours are rare neural neoplasms that show differentiation and are usually low-grade. Unlike gliomas, they do not require aggressive management, and diagnosing and differentiating between these two entities is crucial to determining the treatment paradigm of this disease. Surgery is the treatment of choice for glioneuronal tumours, and the role of adjuvant treatment still needs to be fleshed out.
View Article and Find Full Text PDFCerebral Echinococcosis Mimicking Malignancy on 68Ga-FAPI PET/MR.
Clin Nucl Med
February 2025
Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.
A 52-year-old man presented with headache and dizziness. An MRI revealed a space-occupying lesion suspicious of a glioma. Subsequent 68Ga-FAPI PET/MR showed increased uptake in the lesion located in the right parieto-occipito-temporal lobe (SUVmax 6.
View Article and Find Full Text PDFBiomimetic Nanoparticle Based Targeted mRNA Vaccine Delivery as a Novel Therapy for Glioblastoma Multiforme.
AAPS PharmSciTech
February 2025
Department of Pharmaceutical Sciences, School of Health and Life Sciences, North South University, Plot 15, Block B, Bashundhara R/A, Dhaka, 1229, Bangladesh.
The prognosis for patients with glioblastoma multiforme (GBM), an aggressive and deadly brain tumor, is poor due to the limited therapeutic options available. Biomimetic nanoparticles have emerged as a promising vehicle for targeted mRNA vaccine delivery, thanks to recent advances in nanotechnology. This presents a novel treatment method for GBM.
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