Background: Intrauterine growth restriction (IUGR) is the second leading contributor to the prevailing perinatal mortality and morbidity. It affects 23.8% of newborns around the world and 75% of these affected infants are born in Asia. In Pakistan the incidence of IUGR is around 25%, more than the WHO criteria for triggering a public health action.
Introduction: IUGR is implicated with profound long-term impacts in adult life; like coronary heart disease, NIDDM and abnormal cortisol levels. The effects of the short and long term sequelae are reviewed.
Etiology: IUGR is associated with a wide variety of etiological factors. But the factor unique in its importance to Pakistan is maternal malnutrition. The fetal gene expression is under the influence of nutrition. Growth projection curves showing the interaction between the genetic and environmental factors are discussed.
Surveillance: Identification of IUGR baby in a primary care setting and the options in diagnosis in secondary and tertiary care settings are overviewed.
Conclusion: The roots of this problem, with multi factorial causes are in the socioeconomic infrastructure. This calls for a synergistic approach of reducing this public health issue. Women empowerment can help us to get out of this intergenerational cycle of growth failure. Availability of resources aside, it is also a matter of political will to change things for the better.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
``Prenatally diagnosed gastroschisis: A case report''.
Radiol Case Rep
March 2025
Department of Psychiatry, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra 442001, India.
Gastroschisis represents a congenital malformation characterized by the herniation of abdominal contents through a defect in the abdominal wall, predominantly situated to the right of the umbilical cord. The defect is characterized by the absence of a covering membrane, resulting in the free floating of extruded abdominal contents. Major complications associated with this condition include stillbirth, preterm delivery, and intrauterine growth restriction.
View Article and Find Full Text PDFA Single-Center Retrospective Cohort Study of Biopterin Metabolism Disorders in the United Arab Emirates.
JIMD Rep
January 2025
Genetic and Metabolic Division, Pediatrics Department Tawam Hospital Al Ain UAE.
Background: Tetrahydrobiopterin (BH4) deficiencies comprise a group of five neurometabolic disorders caused by five genetic defects responsible for BH4 biosynthesis and regeneration. Their global prevalence remains unknown, and variance exists among different countries.
Aims: To describe clinical, biochemical, molecular genetic data and follow-up of patients with BH4 deficiency seen in Tawam Hospital.
Effects of maternal vitamin D supplementation on childhood health.
Endocr Rev
January 2025
Dep. of Clinical Medicine, Aarhus University, Denmark.
Vitamin D deficiency during pregnancy is associated with an increased risk of health issues in the offspring. Accordingly, recent Endocrine Society guidelines strongly support supplementation in pregnancy, also underlining that without consensus on optimal maternal vitamin D levels, routine screening is currently irrelevant. Knowledge of organ-specific effects of vitamin D and its association with maternal vitamin D status may aid to optimize vitamin D supplementation.
View Article and Find Full Text PDFComprehensive Clinical and Genetic Characterization of a Spanish Cohort of 22 Patients With Bainbridge-Ropers Syndrome.
Clin Genet
January 2025
Clinical and Molecular Genetics Area, Vall d'Hebron Hospital, Medicine Genetics Group, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
Bainbridge-Ropers Syndrome (BRPS) is a genetic condition resulting from truncating variants in the ASXL3 gene. The clinical features include neurodevelopmental and language impairments, behavioral issues, hypotonia, feeding difficulties, and distinctive facial features. In this retrospective study, we analyzed 22 Spanish individuals with BRPS, aiming to perform a detailed clinical and molecular description and establish a genotype-phenotype correlation.
View Article and Find Full Text PDFPrenatal diagnosis and treatment of fetal intestinal volvulus: A case report.
Medicine (Baltimore)
January 2025
Department of Neonatology, Hangzhou Women's Hospital, Hangzhou, Zhejiang, China.
Rationale: Fetal intestinal volvulus, a rare and severe disorder, poses significant diagnostic challenges prenatally and can lead to intrauterine death or adverse neonatal outcomes if untreated in a timely manner. This study reports a case of fetal intestinal volvulus confirmed postoperatively, providing insights into its clinical manifestations, diagnostic methods, and treatment outcomes, thereby enhancing understanding of this rare condition.
Patient Concerns: A Chinese gravida 2, para 1 female presented at 32 weeks and 5 days of gestation with decreased fetal movements.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!