AI Article Synopsis
- The supernatant from cortisol-resistant thymocytes enhances colony formation and improves survival in sublethally irradiated mice.
- This treatment also boosts the recovery rate of thymocyte numbers post-irradiation and supports a stronger immune response to T-dependent antigens in nude mice.
- The findings imply that cortisol-resistant thymocytes produce a chemotactic factor that helps migrate stem cells from the bone marrow to other parts of the body.
Article Abstract
We present evidence about the functional activity of factors produced by cortisol-resistant thymocytes. Experiments in vivo have shown that the administration of the supernatant prepared from cortisol-resistant thymocytes leads to a strong stimulation of endogenous colony formation, significantly prolongs survival of sublethally irradiated mice, increases the rate of restoration of the number of thymocytes in the thymus after sublethal irradiation, and contributes to the recovery of the humoral immune response of nude mice to T-dependent antigens. The results obtained suggest that along with other cytokines, cortisol-resistant thymocytes spontaneously produce a chemotactic factor inducing migration of stem cells from the bone marrow to the periphery.
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Article Synopsis
- The supernatant from cortisol-resistant thymocytes enhances colony formation and improves survival in sublethally irradiated mice.
- This treatment also boosts the recovery rate of thymocyte numbers post-irradiation and supports a stronger immune response to T-dependent antigens in nude mice.
- The findings imply that cortisol-resistant thymocytes produce a chemotactic factor that helps migrate stem cells from the bone marrow to other parts of the body.
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