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Prophylaxis by a reversible cholinesterase inhibitor and the NMDA receptor antagonist treatment as combinatorial countermeasure against nerve agent poisoning in mice model.
Chem Biol Interact
January 2025
Department of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove, Czech Republic. Electronic address:
The current pharmacological pretreatment and medical treatment of nerve agent poisoning is an insufficiently addressed medical task. The prophylactic efficacy of a novel compound acting dually as an acetylcholinesterase inhibitor and NMDA receptor antagonist (K1959) and the therapeutic efficacy of a novel NMDA receptor antagonist (K2060) were evaluated in the NMRI mice model of nerve agent poisoning by tabun, soman and sarin. Their added value to the standard antidotal treatment (a combination of oxime reactivator and atropine) was also analyzed.
View Article and Find Full Text PDFPharmaceutical Prescribing Privileges for Optometrists to Combat Childhood Myopia in Singapore: Public Health Policy Review and Analysis.
Children (Basel)
December 2024
Institute of Epidemiology and Healthcare, Faculty of Population Health Sciences, University College London, London WC1E 6BT, UK.
Singapore's national myopia prevention efforts have largely focused on school vision screening and public education on outdoor activities in the past two decades. Given the emergence of evidence-based myopia interventions, this policy review and analysis investigates the potential benefits and drawbacks of optometrist prescribing privileges as it has been proposed to reduce the barriers to access effective interventions, such as combined therapy (e.g.
View Article and Find Full Text PDFEfficacy of defocus incorporated multiple segments (DIMS) lenses and low-dose atropine on retarding myopic shift among premyopic preschoolers: Protocol for a prospective, multicenter, randomized controlled trial.
PLoS One
December 2024
Department of Ophthalmology, Lotung Poh-Ai Hospital, Lo-Hsu Medical Foundation, Incorporation, Yilan, Taiwan.
Background: Myopia has been a rising problem globally. Early-onset myopia significantly increases the risk of high myopia later in life. Despite the proven benefits of increased outdoor time, optimal strategies for preventing early-onset myopia in premyopic children need further investigation.
View Article and Find Full Text PDFProteomic analysis of effects of 1% atropine in myopia therapy in Guinea pigs.
Exp Eye Res
December 2024
Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China. Electronic address:
Myopia is a significant global public health issue. Key interventions for managing myopia include atropine treatment, optical correction, and surgical methods. This study focused on evaluating alterations in retinal protein expression after atropine therapy for myopia.
View Article and Find Full Text PDFLow-concentration atropine for controlling myopia onset and progression in East Asia.
Asia Pac J Ophthalmol (Phila)
December 2024
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong; Hong Kong Eye Hospital, Hong Kong; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong; Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China; Department of Ophthalmology, Hong Kong Children's Hospital, Hong Kong. Electronic address:
Purpose: Over the past few years, there has been a rapid accumulation of data on the use of low-concentration atropine for myopia control, especially in East Asian children, with its effectiveness varying in different studies. This review aims to evaluate the current evidence surrounding the efficacy and safety of low-concentration atropine in the management of myopia onset and progression in East Asia.
Methods: Clinical trials involving atropine for myopia control in East Asia were reviewed.
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